Simpson TJ - Search Results

1

Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

Fisch KM, Bakeer W, Yakasai AA, Song Z, Pedrick J, Wasil Z, Bailey AM, Lazarus CM, Simpson TJ, Cox RJ. Fisch KM, et al. Among authors: simpson tj. J Am Chem Soc. 2011 Oct 19;133(41):16635-41. doi: 10.1021/ja206914q. Epub 2011 Sep 26. J Am Chem Soc. 2011. PMID: 21899331

2

Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins.

Cox RJ, Hitchman TS, Byrom KJ, Findlow IS, Tanner JA, Crosby J, Simpson TJ. Cox RJ, et al. Among authors: simpson tj. FEBS Lett. 1997 Apr 1;405(3):267-72. doi: 10.1016/s0014-5793(97)00202-0. FEBS Lett. 1997. PMID: 9108302 Free article.

3

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins.

Hitchman TS, Crosby J, Byrom KJ, Cox RJ, Simpson TJ. Hitchman TS, et al. Among authors: simpson tj. Chem Biol. 1998 Jan;5(1):35-47. doi: 10.1016/s1074-5521(98)90085-0. Chem Biol. 1998. PMID: 9479478

4

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins.

Crosby J, Byrom KJ, Hitchman TS, Cox RJ, Crump MP, Findlow IS, Bibb MJ, Simpson TJ. Crosby J, et al. Among authors: simpson tj. FEBS Lett. 1998 Aug 14;433(1-2):132-8. doi: 10.1016/s0014-5793(98)00840-0. FEBS Lett. 1998. PMID: 9738947 Free article.

5

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor.

Matharu AL, Cox RJ, Crosby J, Byrom KJ, Simpson TJ. Matharu AL, et al. Among authors: simpson tj. Chem Biol. 1998 Dec;5(12):699-711. doi: 10.1016/s1074-5521(98)90663-9. Chem Biol. 1998. PMID: 9862793

6

Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes.

Bingle LE, Simpson TJ, Lazarus CM. Bingle LE, et al. Among authors: simpson tj. Fungal Genet Biol. 1999 Apr;26(3):209-23. doi: 10.1006/fgbi.1999.1115. Fungal Genet Biol. 1999. PMID: 10361035

7

A chain initiation factor common to both modular and aromatic polyketide synthases.

Bisang C, Long PF, Cortés J, Westcott J, Crosby J, Matharu AL, Cox RJ, Simpson TJ, Staunton J, Leadlay PF. Bisang C, et al. Among authors: simpson tj. Nature. 1999 Sep 30;401(6752):502-5. doi: 10.1038/46829. Nature. 1999. PMID: 10519556

8

Design and utility of oligonucleotide gene probes for fungal polyketide synthases.

Nicholson TP, Rudd BA, Dawson M, Lazarus CM, Simpson TJ, Cox RJ. Nicholson TP, et al. Among authors: simpson tj. Chem Biol. 2001 Feb;8(2):157-78. doi: 10.1016/s1074-5521(00)90064-4. Chem Biol. 2001. PMID: 11251290

9

Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.

Szafranska AE, Hitchman TS, Cox RJ, Crosby J, Simpson TJ. Szafranska AE, et al. Among authors: simpson tj. Biochemistry. 2002 Feb 5;41(5):1421-7. doi: 10.1021/bi012001p. Biochemistry. 2002. PMID: 11814333

10

Synthesis and characterisation of acyl carrier protein bound polyketide analogues.

Arthur C, Cox RJ, Crosby J, Rahman MM, Simpson TJ, Soulas F, Spogli R, Szafranska AE, Westcott J, Winfield CJ. Arthur C, et al. Among authors: simpson tj. Chembiochem. 2002 Mar 1;3(2-3):253-7. doi: 10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7. Chembiochem. 2002. PMID: 11921408 No abstract available.

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