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The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.
Bartolommei G, Tadini-Buoninsegni F, Moncelli MR, Gemma S, Camodeca C, Butini S, Campiani G, Lewis D, Inesi G. Bartolommei G, et al. Among authors: camodeca c. J Biol Chem. 2011 Nov 4;286(44):38383-38389. doi: 10.1074/jbc.M111.287276. Epub 2011 Sep 13. J Biol Chem. 2011. PMID: 21914795 Free PMC article.
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: camodeca c. J Med Chem. 2012 Aug 9;55(15):6948-67. doi: 10.1021/jm300802s. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22783984
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: camodeca c. J Med Chem. 2012 Dec 13;55(23):10387-404. doi: 10.1021/jm300831b. Epub 2012 Nov 21. J Med Chem. 2012. PMID: 23145816
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A. Nuti E, et al. Among authors: camodeca c. J Med Chem. 2015 Sep 24;58(18):7224-40. doi: 10.1021/acs.jmedchem.5b00367. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26263024 Free article.
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.
Nuti E, Cuffaro D, Bernardini E, Camodeca C, Panelli L, Chaves S, Ciccone L, Tepshi L, Vera L, Orlandini E, Nencetti S, Stura EA, Santos MA, Dive V, Rossello A. Nuti E, et al. Among authors: camodeca c. J Med Chem. 2018 May 24;61(10):4421-4435. doi: 10.1021/acs.jmedchem.8b00096. Epub 2018 May 16. J Med Chem. 2018. PMID: 29727184
30 results