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1,046 results

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Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.
Lim J, Taoka B, Otte RD, Spencer K, Dinsmore CJ, Altman MD, Chan G, Rosenstein C, Sharma S, Su HP, Szewczak AA, Xu L, Yin H, Zugay-Murphy J, Marshall CG, Young JR. Lim J, et al. Among authors: spencer k. J Med Chem. 2011 Oct 27;54(20):7334-49. doi: 10.1021/jm200909u. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21942426
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
Ellis JM, Altman MD, Bass A, Butcher JW, Byford AJ, Donofrio A, Galloway S, Haidle AM, Jewell J, Kelly N, Leccese EK, Lee S, Maddess M, Miller JR, Moy LY, Osimboni E, Otte RD, Reddy MV, Spencer K, Sun B, Vincent SH, Ward GJ, Woo GH, Yang C, Houshyar H, Northrup AB. Ellis JM, et al. Among authors: spencer k. J Med Chem. 2015 Feb 26;58(4):1929-39. doi: 10.1021/jm5018169. Epub 2015 Feb 16. J Med Chem. 2015. PMID: 25625541
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q. Katz JD, et al. Among authors: spencer kb. J Med Chem. 2011 Jun 23;54(12):4092-108. doi: 10.1021/jm200112k. Epub 2011 May 24. J Med Chem. 2011. PMID: 21608528
Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny BA, Fradera X, Siliphaivanh P, Presland J, Spencer KB, Soisson SM, Popov P, Sarret P, Katritch V, Cherezov V. Michaelian N, et al. Nat Commun. 2021 May 20;12(1):2971. doi: 10.1038/s41467-021-23149-1. Nat Commun. 2021. PMID: 34016973 Free PMC article.
Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD, Mrozowich T, Mortison JD, Rivera C, Smith GF, Burchard J, Dandliker PJ, Patel TR, Nickbarg EB, Lee JT. Aguilar R, et al. Nature. 2022 Apr;604(7904):160-166. doi: 10.1038/s41586-022-04537-z. Epub 2022 Mar 30. Nature. 2022. PMID: 35355011 Free PMC article.
How Many Lymph Nodes are Enough in Paratesticular Rhabdomyosarcoma?
Spencer KA, Levy B, Cranford W, McLouth CJ, Copeland H, Routh JC, Rodeberg DA, Buchanan AF. Spencer KA, et al. J Pediatr Surg. 2024 Oct 29;60(2):162040. doi: 10.1016/j.jpedsurg.2024.162040. Online ahead of print. J Pediatr Surg. 2024. PMID: 39527909
The Efficacy of Blood Flow Restriction Training to Improve Quadriceps Muscle Function after ACL Reconstruction.
Erickson LN, Owen MK, Casadonte KR, Janatova T, Lucas K, Spencer K, Brightwell BD, Graham MC, White M, Thomas NT, Latham CM, Jacobs C, Conley C, Thompson KL, Johnson DL, Hardy P, Fry CS, Noehren B. Erickson LN, et al. Among authors: spencer k. Med Sci Sports Exerc. 2024 Oct 1. doi: 10.1249/MSS.0000000000003573. Online ahead of print. Med Sci Sports Exerc. 2024. PMID: 39350350
1,046 results