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A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. Choi JH, et al. Among authors: morrissey km. Clin Pharmacol Ther. 2011 Nov;90(5):674-84. doi: 10.1038/clpt.2011.165. Epub 2011 Sep 28. Clin Pharmacol Ther. 2011. PMID: 21956618 Free PMC article.
The UCSF-FDA TransPortal: a public drug transporter database.
Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. Morrissey KM, et al. Clin Pharmacol Ther. 2012 Nov;92(5):545-6. doi: 10.1038/clpt.2012.44. Clin Pharmacol Ther. 2012. PMID: 23085876 Free PMC article.
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. Chen L, et al. Among authors: morrissey km. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111. Epub 2014 Jun 24. Proc Natl Acad Sci U S A. 2014. PMID: 24961373 Free PMC article.
Renal transporters in drug development.
Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Morrissey KM, et al. Annu Rev Pharmacol Toxicol. 2013;53:503-29. doi: 10.1146/annurev-pharmtox-011112-140317. Epub 2012 Nov 8. Annu Rev Pharmacol Toxicol. 2013. PMID: 23140242 Review.
Consequences of POR mutations and polymorphisms.
Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM. Miller WL, et al. Among authors: morrissey k. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):174-9. doi: 10.1016/j.mce.2010.10.022. Epub 2010 Nov 9. Mol Cell Endocrinol. 2011. PMID: 21070833 Free PMC article.
34 results