Mekonnen L - Search Results

1

Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation.

Fanta BS, Lenjisa J, Teo T, Kou L, Mekonnen L, Yang Y, Basnet SKC, Hassankhani R, Sykes MJ, Yu M, Wang S. Fanta BS, et al. Among authors: mekonnen l. Molecules. 2023 Mar 25;28(7):2951. doi: 10.3390/molecules28072951. Molecules. 2023. PMID: 37049714 Free PMC article.

2

Kinase inhibitors: Opportunities for small molecule anticancer immunotherapies.

Safaroghli-Azar A, Emadi F, Lenjisa J, Mekonnen L, Wang S. Safaroghli-Azar A, et al. Among authors: mekonnen l. Drug Discov Today. 2023 May;28(5):103525. doi: 10.1016/j.drudis.2023.103525. Epub 2023 Mar 11. Drug Discov Today. 2023. PMID: 36907320 Review.

3

2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation.

Fanta BS, Mekonnen L, Basnet SKC, Teo T, Lenjisa J, Khair NZ, Kou L, Tadesse S, Sykes MJ, Yu M, Wang S. Fanta BS, et al. Among authors: mekonnen l. Bioorg Med Chem. 2023 Feb 15;80:117158. doi: 10.1016/j.bmc.2023.117158. Epub 2023 Jan 11. Bioorg Med Chem. 2023. PMID: 36706608

4

Discovery of Potent Inhibitors of Cyclin-Dependent Kinases 7 and 9: Design, Synthesis, Structure-Activity Relationship Analysis and Biological Evaluation.

Chen R, Hassankhani R, Long Y, Basnet SKC, Teo T, Yang Y, Mekonnen L, Yu M, Wang S. Chen R, et al. Among authors: mekonnen l. ChemMedChem. 2023 Feb 1;18(3):e202200582. doi: 10.1002/cmdc.202200582. Epub 2022 Nov 27. ChemMedChem. 2023. PMID: 36400715

5

Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation.

Yu M, Teo T, Yang Y, Li M, Long Y, Philip S, Noll B, Heinemann GK, Diab S, Eldi P, Mekonnen L, Anshabo AT, Rahaman MH, Milne R, Hayball JD, Wang S. Yu M, et al. Among authors: mekonnen l. Eur J Med Chem. 2021 Mar 15;214:113248. doi: 10.1016/j.ejmech.2021.113248. Epub 2021 Feb 3. Eur J Med Chem. 2021. PMID: 33571827

6

Discovery of CDK5 Inhibitors through Structure-Guided Approach.

Khair NZ, Lenjisa JL, Tadesse S, Kumarasiri M, Basnet SKC, Mekonnen LB, Li M, Diab S, Sykes MJ, Albrecht H, Milne R, Wang S. Khair NZ, et al. Among authors: mekonnen lb. ACS Med Chem Lett. 2019 Mar 20;10(5):786-791. doi: 10.1021/acsmedchemlett.9b00029. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31098000 Free PMC article.

7

Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity.

Abdelaziz AM, Diab S, Islam S, Basnet SKC, Noll B, Li P, Mekonnen LB, Lu J, Albrecht H, Milne RW, Gerber C, Yu M, Wang S. Abdelaziz AM, et al. Among authors: mekonnen lb. Med Chem. 2019;15(6):602-623. doi: 10.2174/1573406415666181219111511. Med Chem. 2019. PMID: 30569866

8

Status of surveillance and routine immunization performances in Amhara Region, Ethiopia: findings from in-depth peer review.

Lakew GA, Wassie E, Ademe A, Fenta A, Wube S, Werede M, Kidane A, Mekonnen L, Hiwot TG, Gallagher K. Lakew GA, et al. Among authors: mekonnen l. Pan Afr Med J. 2017 Jun 9;27(Suppl 2):6. doi: 10.11604/pamj.supp.2017.27.2.10755. eCollection 2017. Pan Afr Med J. 2017. PMID: 28983394 Free PMC article.

9

A novel series of N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amines as highly potent CDK4/6 inhibitors.

Tadesse S, Zhu G, Mekonnen LB, Lenjisa JL, Yu M, Brown MP, Wang S. Tadesse S, et al. Among authors: mekonnen lb. Future Med Chem. 2017 Sep;9(13):1495-1506. doi: 10.4155/fmc-2017-0076. Epub 2017 Aug 10. Future Med Chem. 2017. PMID: 28795589

10

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation.

Tadesse S, Yu M, Mekonnen LB, Lam F, Islam S, Tomusange K, Rahaman MH, Noll B, Basnet SK, Teo T, Albrecht H, Milne R, Wang S. Tadesse S, et al. Among authors: mekonnen lb. J Med Chem. 2017 Mar 9;60(5):1892-1915. doi: 10.1021/acs.jmedchem.6b01670. Epub 2017 Feb 16. J Med Chem. 2017. PMID: 28156111 Free article.

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