He X - Search Results

1

GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer.

Wang Y, He X, Ngeow J, Eng C. Wang Y, et al. Among authors: he x. Hum Mol Genet. 2012 Feb 1;21(3):569-76. doi: 10.1093/hmg/ddr491. Epub 2011 Oct 21. Hum Mol Genet. 2012. PMID: 22021428

2

Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers.

Wang Y, Romigh T, He X, Tan MH, Orloff MS, Silverman RH, Heston WD, Eng C. Wang Y, et al. Among authors: he x. Oncogene. 2011 Oct 20;30(42):4327-38. doi: 10.1038/onc.2011.144. Epub 2011 May 2. Oncogene. 2011. PMID: 21532617

3

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.

Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C. Wang Y, et al. Among authors: he x. Hum Mol Genet. 2010 Nov 15;19(22):4319-29. doi: 10.1093/hmg/ddq354. Epub 2010 Aug 20. Hum Mol Genet. 2010. PMID: 20729295 Free PMC article.

4

Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.

He X, Ni Y, Wang Y, Romigh T, Eng C. He X, et al. Hum Mol Genet. 2011 Jan 1;20(1):80-9. doi: 10.1093/hmg/ddq434. Epub 2010 Oct 6. Hum Mol Genet. 2011. PMID: 20926450 Free PMC article.

5

Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.

He X, Wang Y, Zhu J, Orloff M, Eng C. He X, et al. Cancer Lett. 2011 Feb 28;301(2):168-76. doi: 10.1016/j.canlet.2010.11.012. Epub 2010 Dec 17. Cancer Lett. 2011. PMID: 21168265

6

Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.

Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD, Eng C. Ni Y, et al. Among authors: he x. Hum Mol Genet. 2012 Jan 15;21(2):300-10. doi: 10.1093/hmg/ddr459. Epub 2011 Oct 6. Hum Mol Genet. 2012. PMID: 21979946 Free PMC article.

7

PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.

He X, Saji M, Radhakrishnan D, Romigh T, Ngeow J, Yu Q, Wang Y, Ringel MD, Eng C. He X, et al. J Clin Endocrinol Metab. 2012 Nov;97(11):E2179-87. doi: 10.1210/jc.2012-1991. Epub 2012 Sep 7. J Clin Endocrinol Metab. 2012. PMID: 22962422 Free PMC article.

8

Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.

Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C. Orloff MS, et al. Among authors: he x. Am J Hum Genet. 2013 Jan 10;92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13. Am J Hum Genet. 2013. PMID: 23246288 Free PMC article.

9

Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation.

Wang Y, Radhakrishnan D, He X, Peehl DM, Eng C. Wang Y, et al. Among authors: he x. J Clin Endocrinol Metab. 2013 Mar;98(3):E586-94. doi: 10.1210/jc.2012-3490. Epub 2013 Feb 5. J Clin Endocrinol Metab. 2013. PMID: 23386643 Free PMC article.

10

Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas.

Wang Y, He X, Yu Q, Eng C. Wang Y, et al. Among authors: he x. Hum Mol Genet. 2013 Jun 1;22(11):2263-72. doi: 10.1093/hmg/ddt077. Epub 2013 Feb 14. Hum Mol Genet. 2013. PMID: 23418309

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