Cotterell AJ - Search Results

1

Antagonism of protease-activated receptor 2 protects against experimental colitis.

Lohman RJ, Cotterell AJ, Suen J, Liu L, Do AT, Vesey DA, Fairlie DP. Lohman RJ, et al. Among authors: cotterell aj. J Pharmacol Exp Ther. 2012 Feb;340(2):256-65. doi: 10.1124/jpet.111.187062. Epub 2011 Oct 25. J Pharmacol Exp Ther. 2012. PMID: 22028393

2

Pathway-selective antagonism of proteinase activated receptor 2.

Suen JY, Cotterell A, Lohman RJ, Lim J, Han A, Yau MK, Liu L, Cooper MA, Vesey DA, Fairlie DP. Suen JY, et al. Br J Pharmacol. 2014 Sep;171(17):4112-24. doi: 10.1111/bph.12757. Epub 2014 Jul 2. Br J Pharmacol. 2014. PMID: 24821440 Free PMC article.

3

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats.

Lohman RJ, Cotterell AJ, Barry GD, Liu L, Suen JY, Vesey DA, Fairlie DP. Lohman RJ, et al. Among authors: cotterell aj. FASEB J. 2012 Jul;26(7):2877-87. doi: 10.1096/fj.11-201004. Epub 2012 Mar 30. FASEB J. 2012. PMID: 22467762

4

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Yau MK, Liu L, Lim J, Lohman RJ, Cotterell AJ, Suen JY, Vesey DA, Reid RC, Fairlie DP. Yau MK, et al. Among authors: cotterell aj. Bioorg Med Chem Lett. 2016 Feb 1;26(3):986-991. doi: 10.1016/j.bmcl.2015.12.048. Epub 2015 Dec 17. Bioorg Med Chem Lett. 2016. PMID: 26725028

5

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

Suen JY, Barry GD, Lohman RJ, Halili MA, Cotterell AJ, Le GT, Fairlie DP. Suen JY, et al. Among authors: cotterell aj. Br J Pharmacol. 2012 Mar;165(5):1413-23. doi: 10.1111/j.1476-5381.2011.01610.x. Br J Pharmacol. 2012. PMID: 21806599 Free PMC article.

6

Novel agonists and antagonists for human protease activated receptor 2.

Barry GD, Suen JY, Le GT, Cotterell A, Reid RC, Fairlie DP. Barry GD, et al. J Med Chem. 2010 Oct 28;53(20):7428-40. doi: 10.1021/jm100984y. J Med Chem. 2010. PMID: 20873792

7

Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis.

Lohman RJ, Iyer A, Fairlie TJ, Cotterell A, Gupta P, Reid RC, Vesey DA, Sweet MJ, Fairlie DP. Lohman RJ, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):387-96. doi: 10.1124/jpet.115.229328. Epub 2015 Dec 10. J Pharmacol Exp Ther. 2016. PMID: 26660228

8

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP. Seow V, et al. Among authors: cotterell aj. Sci Rep. 2016 Apr 20;6:24575. doi: 10.1038/srep24575. Sci Rep. 2016. PMID: 27094554 Free PMC article.

9

PAR2 Modulators Derived from GB88.

Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Jiang Y, Cotterell AJ, Barry GD, Mak JY, Vesey DA, Reid RC, Fairlie DP. Yau MK, et al. Among authors: cotterell aj. ACS Med Chem Lett. 2016 Oct 10;7(12):1179-1184. doi: 10.1021/acsmedchemlett.6b00306. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994760 Free PMC article.

10

Mapping transmembrane residues of proteinase activated receptor 2 (PAR₂) that influence ligand-modulated calcium signaling.

Suen JY, Adams MN, Lim J, Madala PK, Xu W, Cotterell AJ, He Y, Yau MK, Hooper JD, Fairlie DP. Suen JY, et al. Among authors: cotterell aj. Pharmacol Res. 2017 Mar;117:328-342. doi: 10.1016/j.phrs.2016.12.020. Epub 2016 Dec 16. Pharmacol Res. 2017. PMID: 27993717

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