Nomme J - Search Results

1

The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1.

Nomme J, Fanning AS, Caffrey M, Lye MF, Anderson JM, Lavie A. Nomme J, et al. J Biol Chem. 2011 Dec 16;286(50):43352-60. doi: 10.1074/jbc.M111.304089. Epub 2011 Oct 26. J Biol Chem. 2011. PMID: 22030391 Free PMC article.

2

Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.

Nomme J, Antanasijevic A, Caffrey M, Van Itallie CM, Anderson JM, Fanning AS, Lavie A. Nomme J, et al. J Biol Chem. 2015 Jul 3;290(27):16595-606. doi: 10.1074/jbc.M115.646695. Epub 2015 May 28. J Biol Chem. 2015. PMID: 26023235 Free PMC article.

3

Free glycine accelerates the autoproteolytic activation of human asparaginase.

Su Y, Karamitros CS, Nomme J, McSorley T, Konrad M, Lavie A. Su Y, et al. Among authors: nomme j. Chem Biol. 2013 Apr 18;20(4):533-40. doi: 10.1016/j.chembiol.2013.03.006. Chem Biol. 2013. PMID: 23601642 Free PMC article.

4

Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.

Nomme J, Murphy JM, Su Y, Sansone ND, Armijo AL, Olson ST, Radu C, Lavie A. Nomme J, et al. Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):68-78. doi: 10.1107/S1399004713025030. Epub 2013 Dec 24. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24419380 Free PMC article.

5

Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis.

Nomme J, Su Y, Lavie A. Nomme J, et al. J Mol Biol. 2014 Jun 26;426(13):2471-85. doi: 10.1016/j.jmb.2014.04.016. Epub 2014 Apr 22. J Mol Biol. 2014. PMID: 24768817 Free PMC article.

6

Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.

Nomme J, Su Y, Konrad M, Lavie A. Nomme J, et al. Biochemistry. 2012 Aug 28;51(34):6816-26. doi: 10.1021/bi300870g. Epub 2012 Aug 14. Biochemistry. 2012. PMID: 22861376 Free PMC article.

7

Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.

Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A. Nomme J, et al. J Med Chem. 2014 Nov 26;57(22):9480-94. doi: 10.1021/jm501124j. Epub 2014 Nov 7. J Med Chem. 2014. PMID: 25341194 Free PMC article.

8

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.

Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Murphy JM, et al. Among authors: nomme j. J Med Chem. 2013 Sep 12;56(17):6696-708. doi: 10.1021/jm400457y. Epub 2013 Aug 15. J Med Chem. 2013. PMID: 23947754 Free PMC article.

9

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.

Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Nathanson DA, et al. Among authors: nomme j. J Exp Med. 2014 Mar 10;211(3):473-86. doi: 10.1084/jem.20131738. Epub 2014 Feb 24. J Exp Med. 2014. PMID: 24567448 Free PMC article.

10

Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.

Nomme J, Renodon-Cornière A, Asanomi Y, Sakaguchi K, Stasiak AZ, Stasiak A, Norden B, Tran V, Takahashi M. Nomme J, et al. J Med Chem. 2010 Aug 12;53(15):5782-91. doi: 10.1021/jm1002974. J Med Chem. 2010. PMID: 20684611 Free PMC article.

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