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PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis.
Iantomasi R, Sali M, Cascioferro A, Palucci I, Zumbo A, Soldini S, Rocca S, Greco E, Maulucci G, De Spirito M, Fraziano M, Fadda G, Manganelli R, Delogu G. Iantomasi R, et al. Among authors: manganelli r. Cell Microbiol. 2012 Mar;14(3):356-67. doi: 10.1111/j.1462-5822.2011.01721.x. Epub 2011 Dec 13. Cell Microbiol. 2012. PMID: 22050772
Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression.
Dainese E, Rodrigue S, Delogu G, Provvedi R, Laflamme L, Brzezinski R, Fadda G, Smith I, Gaudreau L, Palù G, Manganelli R. Dainese E, et al. Among authors: manganelli r. Infect Immun. 2006 Apr;74(4):2457-61. doi: 10.1128/IAI.74.4.2457-2461.2006. Infect Immun. 2006. PMID: 16552079 Free PMC article.
Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in mice.
Sali M, Di Sante G, Cascioferro A, Zumbo A, Nicolò C, Donà V, Rocca S, Procoli A, Morandi M, Ria F, Palù G, Fadda G, Manganelli R, Delogu G. Sali M, et al. Among authors: manganelli r. Infect Immun. 2010 Dec;78(12):5202-13. doi: 10.1128/IAI.00267-10. Epub 2010 Oct 4. Infect Immun. 2010. PMID: 20921146 Free PMC article.
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway.
Daleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, van der Wel N, Peters PJ, Luirink J, Manganelli R, Bitter W. Daleke MH, et al. Among authors: manganelli r. J Biol Chem. 2011 May 27;286(21):19024-34. doi: 10.1074/jbc.M110.204966. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471225 Free PMC article.
158 results