Boswell CA - Search Results

1

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice.

Bumbaca D, Xiang H, Boswell CA, Port RE, Stainton SL, Mundo EE, Ulufatu S, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Bumbaca D, et al. Among authors: boswell ca. Br J Pharmacol. 2012 May;166(1):368-77. doi: 10.1111/j.1476-5381.2011.01777.x. Br J Pharmacol. 2012. PMID: 22074316 Free PMC article.

2

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.

Boswell CA, Ferl GZ, Mundo EE, Schweiger MG, Marik J, Reich MP, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. Mol Pharm. 2010 Oct 4;7(5):1848-57. doi: 10.1021/mp100183k. Epub 2010 Aug 12. Mol Pharm. 2010. PMID: 20704296

3

Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow.

Boswell CA, Ferl GZ, Mundo EE, Bumbaca D, Schweiger MG, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. PLoS One. 2011 Mar 15;6(3):e17874. doi: 10.1371/journal.pone.0017874. PLoS One. 2011. PMID: 21436893 Free PMC article.

4

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, Theil FP, Fielder PJ, Khawli LA, Lin K. Boswell CA, et al. Bioconjug Chem. 2011 Oct 19;22(10):1994-2004. doi: 10.1021/bc200212a. Epub 2011 Oct 3. Bioconjug Chem. 2011. PMID: 21913715

5

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.

Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, Clark S, Ross S, Cheng E, Parsons-Reponte K, Cain G, Van Hoy M, Majidy N, Bheddah S, dela Cruz Chuh J, Kozak KR, Lewin-Koh N, Nauka P, Bumbaca D, Sliwkowski M, Tibbitts J, Theil FP, Fielder PJ, Khawli LA, Boswell CA. Pastuskovas CV, et al. Among authors: boswell ca. Mol Cancer Ther. 2012 Mar;11(3):752-62. doi: 10.1158/1535-7163.MCT-11-0742-T. Epub 2012 Jan 5. Mol Cancer Ther. 2012. PMID: 22222630

6

Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.

Boswell CA, Bumbaca D, Fielder PJ, Khawli LA. Boswell CA, et al. AAPS J. 2012 Sep;14(3):612-8. doi: 10.1208/s12248-012-9374-1. Epub 2012 May 31. AAPS J. 2012. PMID: 22648903 Free PMC article.

7

Differential effects of predosing on tumor and tissue uptake of an 111In-labeled anti-TENB2 antibody-drug conjugate.

Boswell CA, Mundo EE, Zhang C, Stainton SL, Yu SF, Lacap JA, Mao W, Kozak KR, Fourie A, Polakis P, Khawli LA, Lin K. Boswell CA, et al. J Nucl Med. 2012 Sep;53(9):1454-61. doi: 10.2967/jnumed.112.103168. Epub 2012 Aug 7. J Nucl Med. 2012. PMID: 22872740 Free article.

8

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.

Boswell CA, Mundo EE, Firestein R, Zhang C, Mao W, Gill H, Young C, Ljumanovic N, Stainton S, Ulufatu S, Fourie A, Kozak KR, Fuji R, Polakis P, Khawli LA, Lin K. Boswell CA, et al. Br J Pharmacol. 2013 Jan;168(2):445-57. doi: 10.1111/j.1476-5381.2012.02138.x. Br J Pharmacol. 2013. PMID: 22889168 Free PMC article.

9

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Yip V, et al. Among authors: boswell ca. MAbs. 2014 May-Jun;6(3):689-96. doi: 10.4161/mabs.28254. Epub 2014 Feb 26. MAbs. 2014. PMID: 24572100 Free PMC article.

10

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Kamath AV, et al. Among authors: boswell ca. MAbs. 2014;6(6):1631-7. doi: 10.4161/mabs.36107. MAbs. 2014. PMID: 25484068 Free PMC article.

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