Lindholm MW - Search Results

1

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T. Lindholm MW, et al. Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22. Mol Ther. 2012. PMID: 22108858 Free PMC article.

2

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Among authors: lindholm mw. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

3

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J. van Poelgeest EP, et al. Among authors: lindholm mw. Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24. Br J Clin Pharmacol. 2015. PMID: 26261033 Free PMC article. Clinical Trial.

4

LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. Elmén J, et al. Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26. Nature. 2008. PMID: 18368051

5

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM. Gupta N, et al. PLoS One. 2010 May 17;5(5):e10682. doi: 10.1371/journal.pone.0010682. PLoS One. 2010. PMID: 20498851 Free PMC article.

6

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Rottiers V, et al. Among authors: lindholm mw. Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840. Sci Transl Med. 2013. PMID: 24259050 Free PMC article.

7

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death.

Schmidt S, Gallego SF, Zelnik ID, Kovalchuk S, Albæk N, Sprenger RR, Øverup C, Pewzner-Jung Y, Futerman AH, Lindholm MW, Jensen ON, Ejsing CS. Schmidt S, et al. Among authors: lindholm mw. Mol Ther. 2022 Apr 6;30(4):1661-1674. doi: 10.1016/j.ymthe.2021.08.021. Epub 2021 Aug 14. Mol Ther. 2022. PMID: 34400330 Free PMC article.

8

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent.

Pedersen L, Hagedorn PH, Lindholm MW, Lindow M. Pedersen L, et al. Among authors: lindholm mw. Mol Ther Nucleic Acids. 2014 Feb 18;3(2):e149. doi: 10.1038/mtna.2013.72. Mol Ther Nucleic Acids. 2014. PMID: 24549300 Free PMC article.

9

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression.

Buntz A, Killian T, Schmid D, Seul H, Brinkmann U, Ravn J, Lindholm M, Knoetgen H, Haucke V, Mundigl O. Buntz A, et al. Nucleic Acids Res. 2019 Jan 25;47(2):953-969. doi: 10.1093/nar/gky1158. Nucleic Acids Res. 2019. PMID: 30462278 Free PMC article.

10

Altered metabolism of LDL in the arterial wall precedes atherosclerosis regression.

Bartels ED, Christoffersen C, Lindholm MW, Nielsen LB. Bartels ED, et al. Among authors: lindholm mw. Circ Res. 2015 Nov 6;117(11):933-42. doi: 10.1161/CIRCRESAHA.115.307182. Epub 2015 Sep 10. Circ Res. 2015. PMID: 26358193

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