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Akt is altered in an animal model of Huntington's disease and in patients.
Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F. Colin E, et al. Among authors: humbert s. Eur J Neurosci. 2005 Mar;21(6):1478-88. doi: 10.1111/j.1460-9568.2005.03985.x. Eur J Neurosci. 2005. PMID: 15845076
The insulin-like growth factor I (IGF-1)/Akt pathway plays a crucial role in Huntington's disease by phosphorylating the causative protein, polyQ-huntingtin, and abolishing its toxic properties [Humbert et al. (2002)Dev. ...In the present report, we thus aimed to an …
The insulin-like growth factor I (IGF-1)/Akt pathway plays a crucial role in Huntington's disease by phosphorylating the causative pr …
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
Borrell-Pagès M, Canals JM, Cordelières FP, Parker JA, Pineda JR, Grange G, Bryson EA, Guillermier M, Hirsch E, Hantraye P, Cheetham ME, Néri C, Alberch J, Brouillet E, Saudou F, Humbert S. Borrell-Pagès M, et al. Among authors: humbert s. J Clin Invest. 2006 May;116(5):1410-24. doi: 10.1172/JCI27607. Epub 2006 Apr 6. J Clin Invest. 2006. PMID: 16604191 Free PMC article.
Huntingtin regulates mammary stem cell division and differentiation.
Elias S, Thion MS, Yu H, Sousa CM, Lasgi C, Morin X, Humbert S. Elias S, et al. Among authors: humbert s. Stem Cell Reports. 2014 Apr 3;2(4):491-506. doi: 10.1016/j.stemcr.2014.02.011. eCollection 2014 Apr 8. Stem Cell Reports. 2014. PMID: 24749073 Free PMC article.
CAG repeat size in Huntingtin alleles is associated with cancer prognosis.
Thion MS, Tézenas du Montcel S, Golmard JL, Vacher S, Barjhoux L, Sornin V, Cazeneuve C, Bièche I, Sinilnikova O, Stoppa-Lyonnet D, Durr A, Humbert S. Thion MS, et al. Among authors: humbert s. Eur J Hum Genet. 2016 Aug;24(9):1310-5. doi: 10.1038/ejhg.2016.13. Epub 2016 Mar 16. Eur J Hum Genet. 2016. PMID: 26980106 Free PMC article.
185 results