Kneen CO - Search Results

1

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

Street LJ, Baker R, Book T, Kneen CO, MacLeod AM, Merchant KJ, Showell GA, Saunders J, Herbert RH, Freedman SB, et al. Street LJ, et al. Among authors: kneen co. J Med Chem. 1990 Oct;33(10):2690-7. doi: 10.1021/jm00172a003. J Med Chem. 1990. PMID: 2213823

2

Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.

Showell GA, Gibbons TL, Kneen CO, MacLeod AM, Merchant K, Saunders J, Freedman SB, Patel S, Baker R. Showell GA, et al. Among authors: kneen co. J Med Chem. 1991 Mar;34(3):1086-94. doi: 10.1021/jm00107a032. J Med Chem. 1991. PMID: 2002451

3

Novel 5-HT3 antagonists: indol-3-ylspiro(azabicycloalkane-3,5'(4'H)-oxazoles).

Swain CJ, Baker R, Kneen C, Herbert R, Moseley J, Saunders J, Seward EM, Stevenson GI, Beer M, Stanton J, et al. Swain CJ, et al. J Med Chem. 1992 Mar 20;35(6):1019-31. doi: 10.1021/jm00084a007. J Med Chem. 1992. PMID: 1552497

4

Novel 5-HT3 antagonists. Indole oxadiazoles.

Swain CJ, Baker R, Kneen C, Moseley J, Saunders J, Seward EM, Stevenson G, Beer M, Stanton J, Watling K. Swain CJ, et al. J Med Chem. 1991 Jan;34(1):140-51. doi: 10.1021/jm00105a021. J Med Chem. 1991. PMID: 1992112

5

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.

Saunders J, Cassidy M, Freedman SB, Harley EA, Iversen LL, Kneen C, MacLeod AM, Merchant KJ, Snow RJ, Baker R. Saunders J, et al. J Med Chem. 1990 Apr;33(4):1128-38. doi: 10.1021/jm00166a008. J Med Chem. 1990. PMID: 2319559

6

Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988.

Augelli-Szafran CE, Horwell DC, Kneen C, Ortwine DF, Pritchard MC, Purchase TS, Roth BD, Trivedi BK, Hill D, Suman-Chauhan N, Webdale L. Augelli-Szafran CE, et al. Bioorg Med Chem. 1996 Oct;4(10):1733-45. doi: 10.1016/0968-0896(96)00185-x. Bioorg Med Chem. 1996. PMID: 8931944

7

Carboxylate bioisosteres of gabapentin.

Burgos-Lepley CE, Thompson LR, Kneen CO, Osborne SA, Bryans JS, Capiris T, Suman-Chauhan N, Dooley DJ, Donovan CM, Field MJ, Vartanian MG, Kinsora JJ, Lotarski SM, El-Kattan A, Walters K, Cherukury M, Taylor CP, Wustrow DJ, Schwarz JB. Burgos-Lepley CE, et al. Among authors: kneen co. Bioorg Med Chem Lett. 2006 May 1;16(9):2333-6. doi: 10.1016/j.bmcl.2005.05.016. Epub 2005 Jun 8. Bioorg Med Chem Lett. 2006. PMID: 15946842

8

Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.

Bryans JS, Davies N, Gee NS, Dissanayake VU, Ratcliffe GS, Horwell DC, Kneen CO, Morrell AI, Oles RJ, O'Toole JC, Perkins GM, Singh L, Suman-Chauhan N, O'Neill JA. Bryans JS, et al. Among authors: kneen co. J Med Chem. 1998 May 21;41(11):1838-45. doi: 10.1021/jm970649n. J Med Chem. 1998. PMID: 9599234

9

Rationally designed "dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists.

Higginbottom M, Kneen C, Ratcliffe GS. Higginbottom M, et al. J Med Chem. 1992 May 1;35(9):1572-7. doi: 10.1021/jm00087a011. J Med Chem. 1992. PMID: 1578483

10

Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells.

McKernan RM, Gillard NP, Quirk K, Kneen CO, Stevenson GI, Swain CJ, Ragan CI. McKernan RM, et al. Among authors: kneen co. J Biol Chem. 1990 Aug 15;265(23):13572-7. J Biol Chem. 1990. PMID: 2380174 Free article.

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