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Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. Ochoa-Sanchez R, et al. Among authors: fraschini f. J Neurosci. 2011 Dec 14;31(50):18439-52. doi: 10.1523/JNEUROSCI.2676-11.2011. J Neurosci. 2011. PMID: 22171046 Free PMC article.
Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.
Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. Lopez-Canul M, et al. Among authors: fraschini f. Pain. 2015 Feb;156(2):305-317. doi: 10.1097/01.j.pain.0000460311.71572.5f. Pain. 2015. PMID: 25599452
Synthesis and biological activity of new melatonin dimeric derivatives.
Di Giacomo B, Bedini A, Spadoni G, Tarzia G, Fraschini F, Pannacci M, Lucini V. Di Giacomo B, et al. Among authors: fraschini f. Bioorg Med Chem. 2007 Jul 1;15(13):4643-50. doi: 10.1016/j.bmc.2007.03.080. Epub 2007 Mar 30. Bioorg Med Chem. 2007. PMID: 17481904
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Rivara S, Mor M, Silva C, Zuliani V, Vacondio F, Spadoni G, Bedini A, Tarzia G, Lucini V, Pannacci M, Fraschini F, Plazzi PV. Rivara S, et al. Among authors: fraschini f. J Med Chem. 2003 Apr 10;46(8):1429-39. doi: 10.1021/jm020982d. J Med Chem. 2003. PMID: 12672242
262 results