Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line.
Paris I, Dagnino-Subiabre A, Marcelain K, Bennett LB, Caviedes P, Caviedes R, Azar CO, Segura-Aguilar J.
Paris I, et al. Among authors: caviedes p, caviedes r.
J Neurochem. 2001 Apr;77(2):519-29. doi: 10.1046/j.1471-4159.2001.00243.x.
J Neurochem. 2001.
PMID: 11299314
Free article.
We found that the Cu-dopamine complex mediates the uptake of (64)CuSO(4) into the Raul Caviedes substantia nigra-clone 3 (RCSN3) cells, and it is inhibited by the addition of excess dopamine (2 m M) (63%, p < 0.001) and nomifensine (2 microM) (77%, p <
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We found that the Cu-dopamine complex mediates the uptake of (64)CuSO(4) into the Raul Caviedes substantia nigra-clone 3 (RCSN3) cell …