Heyrman R - Search Results

1

The use of modeling and simulation to guide clinical development of olmesartan medoxomil in pediatric subjects.

Salazar DE, Song SH, Shi J, Rohatagi S, Heyrman R, Wada DR, Carrothers TJ. Salazar DE, et al. Among authors: heyrman r. Clin Pharmacol Ther. 2012 Feb;91(2):250-6. doi: 10.1038/clpt.2011.220. Epub 2011 Dec 28. Clin Pharmacol Ther. 2012. PMID: 22205195

2

Pharmacokinetics of amlodipine and olmesartan after administration of amlodipine besylate and olmesartan medoxomil in separate dosage forms and as a fixed-dose combination.

Rohatagi S, Lee J, Shenouda M, Haworth S, Bathala MS, Allison M, Rubets I, Heyrman R, Noveck R, Salazar DE. Rohatagi S, et al. Among authors: heyrman r. J Clin Pharmacol. 2008 Nov;48(11):1309-22. doi: 10.1177/0091270008322176. J Clin Pharmacol. 2008. PMID: 18974285

3

Model-Supported Development of CS-8635: A Fixed-Dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide.

Song S, Carrothers TJ, Moore H, Green M, Miller R, Rohatagi S, Lee J, Wang A, Melino M, Patel M, Heyrman R, Salazar DE. Song S, et al. Among authors: heyrman r. Clin Pharmacol Drug Dev. 2013 Apr;2(2):103-12. doi: 10.1002/cpdd.17. Epub 2013 Mar 16. Clin Pharmacol Drug Dev. 2013. PMID: 27121665

4

Pharmacokinetics of olmesartan medoxomil in pediatric patients with hypertension.

Wells TG, Blowey DL, Sullivan JE, Blumer J, Sherbotie JR, Song S, Rohatagi S, Heyrman R, Salazar DE. Wells TG, et al. Among authors: heyrman r. Paediatr Drugs. 2012 Dec 1;14(6):401-9. doi: 10.2165/11631450-000000000-00000. Paediatr Drugs. 2012. PMID: 22880942 Clinical Trial.

5

The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8-week factorial efficacy and safety study.

Chrysant SG, Melino M, Karki S, Lee J, Heyrman R. Chrysant SG, et al. Among authors: heyrman r. Clin Ther. 2008 Apr;30(4):587-604. doi: 10.1016/j.clinthera.2008.04.002. Clin Ther. 2008. PMID: 18498909 Clinical Trial.

6

Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study.

Oparil S, Melino M, Lee J, Fernandez V, Heyrman R. Oparil S, et al. Among authors: heyrman r. Clin Ther. 2010 Jul;32(7):1252-69. doi: 10.1016/j.clinthera.2010.07.008. Clin Ther. 2010. PMID: 20678674 Clinical Trial.

7

A double-blind, dose-response study of the efficacy and safety of olmesartan medoxomil in children and adolescents with hypertension.

Hazan L, Hernández Rodriguez OA, Bhorat AE, Miyazaki K, Tao B, Heyrman R; Assessment of Efficacy and Safety of Olmesartan in Pediatric Hypertension Study Group. Hazan L, et al. Among authors: heyrman r. Hypertension. 2010 Jun;55(6):1323-30. doi: 10.1161/HYPERTENSIONAHA.109.147702. Epub 2010 Apr 12. Hypertension. 2010. PMID: 20385971 Clinical Trial.

8

Efficacy and safety of long-term treatment with the combination of amlodipine besylate and olmesartan medoxomil in patients with hypertension.

Chrysant SG, Oparil S, Melino M, Karki S, Lee J, Heyrman R. Chrysant SG, et al. Among authors: heyrman r. J Clin Hypertens (Greenwich). 2009 Sep;11(9):475-82. doi: 10.1111/j.1751-7176.2009.00159.x. J Clin Hypertens (Greenwich). 2009. PMID: 19751459 Free PMC article. Clinical Trial.

9

Efficacy and tolerability of amlodipine plus olmesartan medoxomil in patients with difficult-to-treat hypertension.

Chrysant SG, Lee J, Melino M, Karki S, Heyrman R. Chrysant SG, et al. Among authors: heyrman r. J Hum Hypertens. 2010 Nov;24(11):730-8. doi: 10.1038/jhh.2010.5. Epub 2010 Feb 18. J Hum Hypertens. 2010. PMID: 20164847 Free PMC article. Clinical Trial.

10

Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial.

Oparil S, Chrysant SG, Melino M, Lee J, Karki S, Heyrman R. Oparil S, et al. Among authors: heyrman r. J Hum Hypertens. 2010 Dec;24(12):831-8. doi: 10.1038/jhh.2010.16. Epub 2010 Mar 4. J Hum Hypertens. 2010. PMID: 20200547 Free PMC article. Clinical Trial.

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