Van Laethem F - Search Results

1

αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.

Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park JH, Yang JC, Sun PD, Singer A. Tikhonova AN, et al. Among authors: van laethem f. Immunity. 2012 Jan 27;36(1):79-91. doi: 10.1016/j.immuni.2011.11.013. Epub 2011 Dec 29. Immunity. 2012. PMID: 22209676 Free PMC article.

2

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

Sarafova SD, Erman B, Yu Q, Van Laethem F, Guinter T, Sharrow SO, Feigenbaum L, Wildt KF, Ellmeier W, Singer A. Sarafova SD, et al. Among authors: van laethem f. Immunity. 2005 Jul;23(1):75-87. doi: 10.1016/j.immuni.2005.05.011. Immunity. 2005. PMID: 16039581 Free article.

3

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A. Van Laethem F, et al. Immunity. 2007 Nov;27(5):735-50. doi: 10.1016/j.immuni.2007.10.007. Immunity. 2007. PMID: 18023370 Free article.

4

Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

Sarafova SD, Van Laethem F, Adoro S, Guinter T, Sharrow SO, Feigenbaum L, Singer A. Sarafova SD, et al. Among authors: van laethem f. Immunity. 2009 Sep 18;31(3):480-90. doi: 10.1016/j.immuni.2009.07.006. Epub 2009 Sep 10. Immunity. 2009. PMID: 19747858 Free PMC article.

5

MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.

Van Laethem F, Tikhonova AN, Singer A. Van Laethem F, et al. Trends Immunol. 2012 Sep;33(9):437-41. doi: 10.1016/j.it.2012.05.006. Epub 2012 Jul 6. Trends Immunol. 2012. PMID: 22771139 Free PMC article.

6

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A. Van Laethem F, et al. Cell. 2013 Sep 12;154(6):1326-41. doi: 10.1016/j.cell.2013.08.009. Cell. 2013. PMID: 24034254 Free PMC article.

7

Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.

Lu J, Van Laethem F, Saba I, Chu J, Tikhonova AN, Bhattacharya A, Singer A, Sun PD. Lu J, et al. Among authors: van laethem f. J Immunol. 2020 Jun 15;204(12):3351-3359. doi: 10.4049/jimmunol.1901084. Epub 2020 Apr 22. J Immunol. 2020. PMID: 32321756 Free PMC article.

8

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.

Van Laethem F, Saba I, Lu J, Bhattacharya A, Tai X, Guinter TI, Engelhardt B, Alag A, Rojano M, Ashe JM, Hanada KI, Yang JC, Sun PD, Singer A. Van Laethem F, et al. Front Immunol. 2020 Jun 16;11:1216. doi: 10.3389/fimmu.2020.01216. eCollection 2020. Front Immunol. 2020. PMID: 32612609 Free PMC article.

9

MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction.

Van Laethem F, Bhattacharya A, Craveiro M, Lu J, Sun PD, Singer A. Van Laethem F, et al. Front Immunol. 2022 Jul 14;13:953160. doi: 10.3389/fimmu.2022.953160. eCollection 2022. Front Immunol. 2022. PMID: 35911724 Free PMC article. Review.

10

Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.

Adoro S, Erman B, Sarafova SD, Van Laethem F, Park JH, Feigenbaum L, Singer A. Adoro S, et al. Among authors: van laethem f. J Immunol. 2008 Nov 15;181(10):6975-83. doi: 10.4049/jimmunol.181.10.6975. J Immunol. 2008. PMID: 18981117 Free PMC article.

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