Nower PT - Search Results

1

Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.

Wang C, Huang H, Valera L, Sun JH, O'Boyle DR 2nd, Nower PT, Jia L, Qiu D, Huang X, Altaf A, Gao M, Fridell RA. Wang C, et al. Among authors: nower pt. Antimicrob Agents Chemother. 2012 Mar;56(3):1350-8. doi: 10.1128/AAC.05977-11. Epub 2012 Jan 3. Antimicrob Agents Chemother. 2012. PMID: 22214777 Free PMC article.

2

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

Fridell RA, Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M. Fridell RA, et al. Hepatology. 2011 Dec;54(6):1924-35. doi: 10.1002/hep.24594. Hepatology. 2011. PMID: 21809362 Clinical Trial.

3

Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052.

Sun JH, O'Boyle Ii DR, Zhang Y, Wang C, Nower P, Valera L, Roberts S, Nettles RE, Fridell RA, Gao M. Sun JH, et al. Hepatology. 2012 Jun;55(6):1692-9. doi: 10.1002/hep.25581. Hepatology. 2012. PMID: 22234905

4

Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir.

Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Roberts S, Fridell RA, Gao M. Wang C, et al. Antimicrob Agents Chemother. 2013 May;57(5):2054-65. doi: 10.1128/AAC.02494-12. Epub 2013 Feb 12. Antimicrob Agents Chemother. 2013. PMID: 23403428 Free PMC article. Clinical Trial.

5

Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity.

Wang C, Jia L, O'Boyle DR 2nd, Sun JH, Rigat K, Valera L, Nower P, Huang X, Kienzle B, Roberts S, Gao M, Fridell RA. Wang C, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5155-63. doi: 10.1128/AAC.02788-14. Epub 2014 Jun 16. Antimicrob Agents Chemother. 2014. PMID: 24936600 Free PMC article.

6

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Sun JH, O'Boyle DR 2nd, Fridell RA, Langley DR, Wang C, Roberts SB, Nower P, Johnson BM, Moulin F, Nophsker MJ, Wang YK, Liu M, Rigat K, Tu Y, Hewawasam P, Kadow J, Meanwell NA, Cockett M, Lemm JA, Kramer M, Belema M, Gao M. Sun JH, et al. Nature. 2015 Nov 12;527(7577):245-8. doi: 10.1038/nature15711. Epub 2015 Nov 4. Nature. 2015. PMID: 26536115

7

Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.

O'Boyle DR 2nd, Nower PT, Lemm JA, Valera L, Sun JH, Rigat K, Colonno R, Gao M. O'Boyle DR 2nd, et al. Among authors: nower pt. Antimicrob Agents Chemother. 2005 Apr;49(4):1346-53. doi: 10.1128/AAC.49.4.1346-1353.2005. Antimicrob Agents Chemother. 2005. PMID: 15793110 Free PMC article.

8

Identification of hepatitis C virus NS5A inhibitors.

Lemm JA, O'Boyle D 2nd, Liu M, Nower PT, Colonno R, Deshpande MS, Snyder LB, Martin SW, St Laurent DR, Serrano-Wu MH, Romine JL, Meanwell NA, Gao M. Lemm JA, et al. Among authors: nower pt. J Virol. 2010 Jan;84(1):482-91. doi: 10.1128/JVI.01360-09. J Virol. 2010. PMID: 19812153 Free PMC article.

9

Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.

Lemm JA, Leet JE, O'Boyle DR 2nd, Romine JL, Huang XS, Schroeder DR, Alberts J, Cantone JL, Sun JH, Nower PT, Martin SW, Serrano-Wu MH, Meanwell NA, Snyder LB, Gao M. Lemm JA, et al. Among authors: nower pt. Antimicrob Agents Chemother. 2011 Aug;55(8):3795-802. doi: 10.1128/AAC.00146-11. Epub 2011 May 16. Antimicrob Agents Chemother. 2011. PMID: 21576451 Free PMC article.

10

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

Qiu D, Lemm JA, O'Boyle DR, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA. Qiu D, et al. Among authors: nower pt. J Gen Virol. 2011 Nov;92(Pt 11):2502-2511. doi: 10.1099/vir.0.034801-0. Epub 2011 Jul 27. J Gen Virol. 2011. PMID: 21795470

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