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Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Suchiman HE, Jacobsen R, McGue M, Stevnsner T, Bohr VA, de Craen AJ, Westendorp RG, Schreiber S, Slagboom PE, Nebel A, Vaupel JW, Christensen K, Christiansen L. Soerensen M, et al. Among authors: suchiman he. Age (Dordr). 2013 Apr;35(2):487-500. doi: 10.1007/s11357-011-9373-7. Epub 2012 Jan 12. Age (Dordr). 2013. PMID: 22234866 Free PMC article.
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Houtman E, et al. Among authors: suchiman hed. Rheumatology (Oxford). 2022 Dec 23;62(1):457-466. doi: 10.1093/rheumatology/keac202. Rheumatology (Oxford). 2022. PMID: 35383365 Free PMC article.
Combined association and linkage analysis applied to the APOE locus.
Beekman M, Posthuma D, Heijmans BT, Lakenberg N, Suchiman HE, Snieder H, de Knijff P, Frants RR, van Ommen GJ, Kluft C, Vogler GP, Slagboom PE, Boomsma DI. Beekman M, et al. Among authors: suchiman he. Genet Epidemiol. 2004 May;26(4):328-37. doi: 10.1002/gepi.10318. Genet Epidemiol. 2004. PMID: 15095392 Free article.
Vitamin D receptor gene polymorphisms have negligible effect on human height.
Macgregor S, Hottenga JJ, Lind PA, Suchiman HE, Willemsen G, Slagboom PE, Montgomery GW, Martin NG, Visscher PM, Boomsma DI. Macgregor S, et al. Among authors: suchiman he. Twin Res Hum Genet. 2008 Oct;11(5):488-94. doi: 10.1375/twin.11.5.488. Twin Res Hum Genet. 2008. PMID: 18828731
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. Beekman M, et al. Among authors: suchiman he. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18046-9. doi: 10.1073/pnas.1003540107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921414 Free PMC article.
Influence of candidate genes on attention problems in children: a longitudinal study.
van Beijsterveldt CE, Middeldorp CM, Slof-Op't Landt MC, Bartels M, Hottenga JJ, Suchiman HE, Slagboom PE, Boomsma DI. van Beijsterveldt CE, et al. Among authors: suchiman he. Behav Genet. 2011 Jan;41(1):155-64. doi: 10.1007/s10519-010-9406-5. Epub 2010 Oct 30. Behav Genet. 2011. PMID: 21049304 Free PMC article.
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: suchiman he. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L. Soerensen M, et al. Among authors: suchiman he. Exp Gerontol. 2012 May;47(5):379-87. doi: 10.1016/j.exger.2012.02.010. Epub 2012 Mar 3. Exp Gerontol. 2012. PMID: 22406557 Free PMC article.
91 results