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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP. Chiavarina B, et al. Among authors: witkiewicz ak. Cancer Biol Ther. 2011 Dec 15;12(12):1101-13. doi: 10.4161/cbt.12.12.18703. Epub 2011 Dec 15. Cancer Biol Ther. 2011. PMID: 22236875 Free PMC article.
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.
Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, Minkeu A, Allen KG, Danilo C, Sotgia F, Bonuccelli G, Jasmin JF, Xu H, Bosco E, Aronow B, Witkiewicz A, Pestell RG, Knudsen ES, Lisanti MP. Mercier I, et al. Cancer Biol Ther. 2008 Aug;7(8):1212-25. doi: 10.4161/cbt.7.8.6220. Epub 2008 Aug 30. Cancer Biol Ther. 2008. PMID: 18458534 Free PMC article.
Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.
Sotgia F, Casimiro MC, Bonuccelli G, Liu M, Whitaker-Menezes D, Er O, Daumer KM, Mercier I, Witkiewicz AK, Minetti C, Capozza F, Gormley M, Quong AA, Rui H, Frank PG, Milliman JN, Knudsen ES, Zhou J, Wang C, Pestell RG, Lisanti MP. Sotgia F, et al. Among authors: witkiewicz ak. Am J Pathol. 2009 Feb;174(2):613-29. doi: 10.2353/ajpath.2009.080653. Am J Pathol. 2009. PMID: 19164602 Free PMC article.
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
Sotgia F, Del Galdo F, Casimiro MC, Bonuccelli G, Mercier I, Whitaker-Menezes D, Daumer KM, Zhou J, Wang C, Katiyar S, Xu H, Bosco E, Quong AA, Aronow B, Witkiewicz AK, Minetti C, Frank PG, Jimenez SA, Knudsen ES, Pestell RG, Lisanti MP. Sotgia F, et al. Among authors: witkiewicz ak. Am J Pathol. 2009 Mar;174(3):746-61. doi: 10.2353/ajpath.2009.080658. Am J Pathol. 2009. PMID: 19234134 Free PMC article.
Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions.
Mercier I, Casimiro MC, Zhou J, Wang C, Plymire C, Bryant KG, Daumer KM, Sotgia F, Bonuccelli G, Witkiewicz AK, Lin J, Tran TH, Milliman J, Frank PG, Jasmin JF, Rui H, Pestell RG, Lisanti MP. Mercier I, et al. Among authors: witkiewicz ak. Am J Pathol. 2009 Apr;174(4):1172-90. doi: 10.2353/ajpath.2009.080882. Am J Pathol. 2009. PMID: 19342371 Free PMC article.
177 results