Pyun HJ - Search Results

1

Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity.

Sheng XC, Casarez A, Cai R, Clarke MO, Chen X, Cho A, Delaney WE 4th, Doerffler E, Ji M, Mertzman M, Pakdaman R, Pyun HJ, Rowe T, Wu Q, Xu J, Kim CU. Sheng XC, et al. Among authors: pyun hj. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1394-6. doi: 10.1016/j.bmcl.2011.12.038. Epub 2011 Dec 13. Bioorg Med Chem Lett. 2012. PMID: 22244938

2

Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors.

Sheng XC, Pyun HJ, Chaudhary K, Wang J, Doerffler E, Fleury M, McMurtrie D, Chen X, Delaney WE 4th, Kim CU. Sheng XC, et al. Among authors: pyun hj. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3453-7. doi: 10.1016/j.bmcl.2009.05.023. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19477126

3

Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney WE 4th, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, Xu J, Kim CU. Sheng XC, et al. Among authors: pyun hj. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2629-34. doi: 10.1016/j.bmcl.2012.01.017. Epub 2012 Feb 1. Bioorg Med Chem Lett. 2012. PMID: 22366653 Clinical Trial.

4

Highly potent HCV NS4B inhibitors with activity against multiple genotypes.

Phillips B, Cai R, Delaney W, Du Z, Ji M, Jin H, Lee J, Li J, Niedziela-Majka A, Mish M, Pyun HJ, Saugier J, Tirunagari N, Wang J, Yang H, Wu Q, Sheng C, Zonte C. Phillips B, et al. Among authors: pyun hj. J Med Chem. 2014 Mar 13;57(5):2161-6. doi: 10.1021/jm401646w. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24512292

5

Design, synthesis and evaluation of a series of novel fumagillin analogues.

Fardis M, Pyun HJ, Tario J, Jin H, Kim CU, Ruckman J, Lin Y, Green L, Hicke B. Fardis M, et al. Among authors: pyun hj. Bioorg Med Chem. 2003 Nov 17;11(23):5051-8. doi: 10.1016/j.bmc.2003.08.031. Bioorg Med Chem. 2003. PMID: 14604668

6

Investigation of novel fumagillin analogues as angiogenesis inhibitors.

Pyun HJ, Fardis M, Tario J, Yang CY, Ruckman J, Henninger D, Jin H, Kim CU. Pyun HJ, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):91-4. doi: 10.1016/j.bmcl.2003.10.008. Bioorg Med Chem Lett. 2004. PMID: 14684305

7

Cellular uptake mechanism of TCTP-PTD in human lung carcinoma cells.

Kim HY, Kim S, Pyun HJ, Maeng J, Lee K. Kim HY, et al. Among authors: pyun hj. Mol Pharm. 2015 Jan 5;12(1):194-203. doi: 10.1021/mp500547f. Epub 2014 Nov 25. Mol Pharm. 2015. PMID: 25423047

8

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease.

Clarke MO, Chen X, Cho A, Delaney WE 4th, Doerffler E, Fardis M, Ji M, Mertzman M, Pakdaman R, Pyun HJ, Rowe T, Yang CY, Sheng XC, Kim CU. Clarke MO, et al. Among authors: pyun hj. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3568-72. doi: 10.1016/j.bmcl.2011.04.125. Epub 2011 May 3. Bioorg Med Chem Lett. 2011. PMID: 21601450

9

Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, Christianson DW. Vedula LS, et al. Among authors: pyun hj. Biochemistry. 2005 Apr 26;44(16):6153-63. doi: 10.1021/bi050059o. Biochemistry. 2005. PMID: 15835903

10

Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.

Digits JA, Pyun HJ, Coates RM, Casey PJ. Digits JA, et al. Among authors: pyun hj. J Biol Chem. 2002 Oct 25;277(43):41086-93. doi: 10.1074/jbc.M208069200. Epub 2002 Aug 16. J Biol Chem. 2002. PMID: 12186880 Free article.

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