Alonso-Gil S - Search Results

1

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

Palomo V, Perez DI, Perez C, Morales-Garcia JA, Soteras I, Alonso-Gil S, Encinas A, Castro A, Campillo NE, Perez-Castillo A, Gil C, Martinez A. Palomo V, et al. J Med Chem. 2012 Feb 23;55(4):1645-61. doi: 10.1021/jm201463v. Epub 2012 Feb 3. J Med Chem. 2012. PMID: 22257026

2

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.

Morales-García JA, Susín C, Alonso-Gil S, Pérez DI, Palomo V, Pérez C, Conde S, Santos A, Gil C, Martínez A, Pérez-Castillo A. Morales-García JA, et al. ACS Chem Neurosci. 2013 Feb 20;4(2):350-60. doi: 10.1021/cn300182g. Epub 2012 Dec 5. ACS Chem Neurosci. 2013. PMID: 23421686 Free PMC article.

3

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.

Redondo M, Brea J, Perez DI, Soteras I, Val C, Perez C, Morales-García JA, Alonso-Gil S, Paul-Fernandez N, Martin-Alvarez R, Cadavid MI, Loza MI, Perez-Castillo A, Mengod G, Campillo NE, Martinez A, Gil C. Redondo M, et al. J Med Chem. 2012 Apr 12;55(7):3274-84. doi: 10.1021/jm201720d. Epub 2012 Mar 16. J Med Chem. 2012. PMID: 22385507 Free article.

4

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.

Chavarría C, Perez DI, Pérez C, Morales Garcia JA, Alonso-Gil S, Pérez-Castillo A, Gil C, Souza JM, Porcal W. Chavarría C, et al. Eur J Med Chem. 2012 Dec;58:44-9. doi: 10.1016/j.ejmech.2012.09.044. Epub 2012 Oct 5. Eur J Med Chem. 2012. PMID: 23085773

5

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

Morales-Garcia JA, Luna-Medina R, Alonso-Gil S, Sanz-Sancristobal M, Palomo V, Gil C, Santos A, Martinez A, Perez-Castillo A. Morales-Garcia JA, et al. ACS Chem Neurosci. 2012 Nov 21;3(11):963-71. doi: 10.1021/cn300110c. Epub 2012 Sep 24. ACS Chem Neurosci. 2012. PMID: 23173075 Free PMC article.

6

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.

Morales-Garcia JA, Palomo V, Redondo M, Alonso-Gil S, Gil C, Martinez A, Perez-Castillo A. Morales-Garcia JA, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):194-204. doi: 10.1021/cn400166d. Epub 2014 Jan 17. ACS Chem Neurosci. 2014. PMID: 24437940 Free PMC article.

7

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.

López-Iglesias B, Pérez C, Morales-García JA, Alonso-Gil S, Pérez-Castillo A, Romero A, López MG, Villarroya M, Conde S, Rodríguez-Franco MI. López-Iglesias B, et al. J Med Chem. 2014 May 8;57(9):3773-85. doi: 10.1021/jm5000613. Epub 2014 Apr 28. J Med Chem. 2014. PMID: 24738476

8

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.

García AM, Brea J, Morales-García JA, Perez DI, González A, Alonso-Gil S, Gracia-Rubio I, Ros-Simó C, Conde S, Cadavid MI, Loza MI, Perez-Castillo A, Valverde O, Martinez A, Gil C. García AM, et al. J Med Chem. 2014 Oct 23;57(20):8590-607. doi: 10.1021/jm501090m. Epub 2014 Oct 8. J Med Chem. 2014. PMID: 25264825

9

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

de la Fuente Revenga M, Fernández-Sáez N, Herrera-Arozamena C, Morales-García JA, Alonso-Gil S, Pérez-Castillo A, Caignard DH, Rivara S, Rodríguez-Franco MI. de la Fuente Revenga M, et al. J Med Chem. 2015 Jun 25;58(12):4998-5014. doi: 10.1021/acs.jmedchem.5b00245. Epub 2015 Jun 10. J Med Chem. 2015. PMID: 26023814

10

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.

Morales-Garcia JA, Redondo M, Alonso-Gil S, Gil C, Perez C, Martinez A, Santos A, Perez-Castillo A. Morales-Garcia JA, et al. PLoS One. 2011 Feb 24;6(2):e17240. doi: 10.1371/journal.pone.0017240. PLoS One. 2011. PMID: 21390306 Free PMC article.

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