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Page 1
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Keller TL, et al. Among authors: edenius m. Nat Chem Biol. 2012 Feb 12;8(3):311-7. doi: 10.1038/nchembio.790. Nat Chem Biol. 2012. PMID: 22327401 Free PMC article.
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Kim Y, et al. Among authors: edenius m. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8900-8911. doi: 10.1073/pnas.1913788117. Epub 2020 Apr 6. Proc Natl Acad Sci U S A. 2020. PMID: 32253314 Free PMC article.
A secreted tyrosine kinase acts in the extracellular environment.
Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Bordoli MR, et al. Among authors: edenius m. Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Cell. 2014. PMID: 25171405 Free PMC article.