Koivunen P - Search Results

1

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr. Koivunen P, et al. Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898. Nature. 2012. PMID: 22343896 Free PMC article.

2

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J. Koivunen P, et al. J Biol Chem. 2006 Sep 29;281(39):28712-20. doi: 10.1074/jbc.M604628200. Epub 2006 Aug 1. J Biol Chem. 2006. PMID: 16885164 Free article.

3

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J. Koivunen P, et al. J Biol Chem. 2007 Feb 16;282(7):4524-4532. doi: 10.1074/jbc.M610415200. Epub 2006 Dec 19. J Biol Chem. 2007. PMID: 17182618 Free article.

4

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles.

Myllyharju J, Koivunen P. Myllyharju J, et al. Among authors: koivunen p. Biol Chem. 2013 Apr;394(4):435-48. doi: 10.1515/hsz-2012-0328. Biol Chem. 2013. PMID: 23324380 Review.

5

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr. Losman JA, et al. Among authors: koivunen p. Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7. Science. 2013. PMID: 23393090 Free PMC article.

6

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.

Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P. Kerkelä R, et al. Among authors: koivunen p. Mol Cell Biol. 2013 Aug;33(16):3321-9. doi: 10.1128/MCB.00432-13. Epub 2013 Jun 17. Mol Cell Biol. 2013. PMID: 23775121 Free PMC article.

7

HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction.

Rahtu-Korpela L, Karsikas S, Hörkkö S, Blanco Sequeiros R, Lammentausta E, Mäkelä KA, Herzig KH, Walkinshaw G, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. Rahtu-Korpela L, et al. Among authors: koivunen p. Diabetes. 2014 Oct;63(10):3324-33. doi: 10.2337/db14-0472. Epub 2014 May 1. Diabetes. 2014. PMID: 24789921

8

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: koivunen p. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.

9

A genetic mechanism for Tibetan high-altitude adaptation.

Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT. Lorenzo FR, et al. Among authors: koivunen p. Nat Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067. Epub 2014 Aug 17. Nat Genet. 2014. PMID: 25129147 Free PMC article.

10

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG Jr, Godley LA, Koivunen P. Laukka T, et al. Among authors: koivunen p. J Biol Chem. 2016 Feb 19;291(8):4256-65. doi: 10.1074/jbc.M115.688762. Epub 2015 Dec 23. J Biol Chem. 2016. PMID: 26703470 Free PMC article.

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