Kleiner RE - Search Results

1

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.

Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Georghiou G, et al. Among authors: kleiner re. Nat Chem Biol. 2012 Feb 19;8(4):366-74. doi: 10.1038/nchembio.792. Nat Chem Biol. 2012. PMID: 22344177 Free PMC article.

2

Global Discovery of Covalent Modulators of Ribonucleoprotein Granules.

Ciancone AM, Seo KW, Chen M, Borne AL, Libby AH, Bai DL, Kleiner RE, Hsu KL. Ciancone AM, et al. Among authors: kleiner re. J Am Chem Soc. 2023 May 24;145(20):11056-11066. doi: 10.1021/jacs.3c00165. Epub 2023 May 9. J Am Chem Soc. 2023. PMID: 37159397 Free PMC article.

3

DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. Kleiner RE, et al. J Am Chem Soc. 2008 Apr 9;130(14):4646-59. doi: 10.1021/ja0753997. Epub 2008 Mar 15. J Am Chem Soc. 2008. PMID: 18341334 Free PMC article.

4

An in vitro translation, selection and amplification system for peptide nucleic acids.

Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. Brudno Y, et al. Among authors: kleiner re. Nat Chem Biol. 2010 Feb;6(2):148-55. doi: 10.1038/nchembio.280. Epub 2009 Dec 27. Nat Chem Biol. 2010. PMID: 20081830 Free PMC article.

5

In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors.

Kleiner RE, Dumelin CE, Tiu GC, Sakurai K, Liu DR. Kleiner RE, et al. J Am Chem Soc. 2010 Aug 25;132(33):11779-91. doi: 10.1021/ja104903x. J Am Chem Soc. 2010. PMID: 20681606 Free PMC article.

6

Small-molecule discovery from DNA-encoded chemical libraries.

Kleiner RE, Dumelin CE, Liu DR. Kleiner RE, et al. Chem Soc Rev. 2011 Dec;40(12):5707-17. doi: 10.1039/c1cs15076f. Epub 2011 Jun 14. Chem Soc Rev. 2011. PMID: 21674077 Free PMC article. Review.

7

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Maianti JP, et al. Among authors: kleiner re. Nature. 2014 Jul 3;511(7507):94-8. doi: 10.1038/nature13297. Epub 2014 May 21. Nature. 2014. PMID: 24847884 Free PMC article.

8

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

Aleem S, Georghiou G, Kleiner RE, Guja K, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Aleem S, et al. Among authors: kleiner re. Cell Chem Biol. 2016 Sep 22;23(9):1103-1112. doi: 10.1016/j.chembiol.2016.07.017. Epub 2016 Sep 1. Cell Chem Biol. 2016. PMID: 27593110 Free PMC article.

9

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM. Kleiner RE, et al. Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7. Nat Chem Biol. 2015. PMID: 26344695 Free PMC article.

10

Site-specific chemistry on the microtubule polymer.

Kleiner RE, Ti SC, Kapoor TM. Kleiner RE, et al. J Am Chem Soc. 2013 Aug 28;135(34):12520-3. doi: 10.1021/ja405199h. Epub 2013 Aug 15. J Am Chem Soc. 2013. PMID: 23930594 Free PMC article.

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