Josephine HR - Search Results

1

Identification and application of NEDD8 E1 inhibitors.

Bruzzese FJ, Milhollen MA, Gavin JM, Josephine HR, Brownell JE. Bruzzese FJ, et al. Among authors: josephine hr. Methods Mol Biol. 2012;832:577-88. doi: 10.1007/978-1-61779-474-2_40. Methods Mol Biol. 2012. PMID: 22350913

2

Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".

Silvaggi NR, Josephine HR, Kuzin AP, Nagarajan R, Pratt RF, Kelly JA. Silvaggi NR, et al. Among authors: josephine hr. J Mol Biol. 2005 Jan 21;345(3):521-33. doi: 10.1016/j.jmb.2004.10.076. J Mol Biol. 2005. PMID: 15581896

3

Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.

Sauvage E, Powell AJ, Heilemann J, Josephine HR, Charlier P, Davies C, Pratt RF. Sauvage E, et al. Among authors: josephine hr. J Mol Biol. 2008 Aug 29;381(2):383-93. doi: 10.1016/j.jmb.2008.06.012. Epub 2008 Jun 10. J Mol Biol. 2008. PMID: 18602645 Free PMC article.

4

The perfect penicillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic beta-lactams.

Josephine HR, Kumar I, Pratt RF. Josephine HR, et al. J Am Chem Soc. 2004 Jul 7;126(26):8122-3. doi: 10.1021/ja048850s. J Am Chem Soc. 2004. PMID: 15225046

5

Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?

Josephine HR, Charlier P, Davies C, Nicholas RA, Pratt RF. Josephine HR, et al. Biochemistry. 2006 Dec 26;45(51):15873-83. doi: 10.1021/bi061804f. Epub 2006 Dec 1. Biochemistry. 2006. PMID: 17176110 Free article.

6

Reactions of peptidoglycan-mimetic beta-lactams with penicillin-binding proteins in vivo and in membranes.

Kumar I, Josephine HR, Pratt RF. Kumar I, et al. Among authors: josephine hr. ACS Chem Biol. 2007 Sep 21;2(9):620-4. doi: 10.1021/cb7001347. ACS Chem Biol. 2007. PMID: 17894439 Free PMC article.

7

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.

Caravella JA, Lin J, Diebold RB, Campbell AM, Ericsson A, Gustafson G, Wang Z, Castro J, Clarke A, Gotur D, Josephine HR, Katz M, Kershaw M, Yao L, Toms AV, Barr KJ, Dinsmore CJ, Walker D, Ashwell S, Lu W. Caravella JA, et al. Among authors: josephine hr. J Med Chem. 2020 Feb 27;63(4):1612-1623. doi: 10.1021/acs.jmedchem.9b01423. Epub 2020 Feb 12. J Med Chem. 2020. PMID: 31971798

8

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.

Lin J, Lu W, Caravella JA, Campbell AM, Diebold RB, Ericsson A, Fritzen E, Gustafson GR, Lancia DR Jr, Shelekhin T, Wang Z, Castro J, Clarke A, Gotur D, Josephine HR, Katz M, Diep H, Kershaw M, Yao L, Kauffman G, Hubbs SE, Luke GP, Toms AV, Wang L, Bair KW, Barr KJ, Dinsmore C, Walker D, Ashwell S. Lin J, et al. Among authors: josephine hr. J Med Chem. 2019 Jul 25;62(14):6575-6596. doi: 10.1021/acs.jmedchem.9b00362. Epub 2019 Jul 8. J Med Chem. 2019. PMID: 31199148

9

Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase.

Riera TV, Zheng L, Josephine HR, Min D, Yang W, Hedstrom L. Riera TV, et al. Among authors: josephine hr. Biochemistry. 2011 Oct 4;50(39):8508-18. doi: 10.1021/bi200785s. Epub 2011 Sep 9. Biochemistry. 2011. PMID: 21870820 Free PMC article.

10

The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase.

Josephine HR, Ravichandran KR, Hedstrom L. Josephine HR, et al. Biochemistry. 2010 Dec 21;49(50):10674-81. doi: 10.1021/bi101590c. Epub 2010 Nov 23. Biochemistry. 2010. PMID: 21062060 Free PMC article.

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