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Microbial scout hypothesis and microbial discovery.
Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS. Buerger S, et al. Among authors: epstein ss. Appl Environ Microbiol. 2012 May;78(9):3229-33. doi: 10.1128/AEM.07308-11. Epub 2012 Feb 24. Appl Environ Microbiol. 2012. PMID: 22367084 Free PMC article.
A trap for in situ cultivation of filamentous actinobacteria.
Gavrish E, Bollmann A, Epstein S, Lewis K. Gavrish E, et al. J Microbiol Methods. 2008 Mar;72(3):257-62. doi: 10.1016/j.mimet.2007.12.009. Epub 2008 Feb 5. J Microbiol Methods. 2008. PMID: 18255181 Free PMC article.
A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K. Gavrish E, et al. Chem Biol. 2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27. Chem Biol. 2014. PMID: 24684906 Free PMC article.
222 results