Lai Y - Search Results

1

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.

Bi YA, Kimoto E, Sevidal S, Jones HM, Barton HA, Kempshall S, Whalen KM, Zhang H, Ji C, Fenner KS, El-Kattan AF, Lai Y. Bi YA, et al. Among authors: lai y. Drug Metab Dispos. 2012 Jun;40(6):1085-92. doi: 10.1124/dmd.111.043489. Epub 2012 Mar 1. Drug Metab Dispos. 2012. PMID: 22381335 Review.

2

Structure-activity relationships for interaction with multidrug resistance protein 2 (ABCC2/MRP2): the role of torsion angle for a series of biphenyl-substituted heterocycles.

Lai Y, Xing L, Poda GI, Hu Y. Lai Y, et al. Drug Metab Dispos. 2007 Jun;35(6):937-45. doi: 10.1124/dmd.106.013250. Epub 2007 Mar 19. Drug Metab Dispos. 2007. PMID: 17371800

3

Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry.

Li N, Nemirovskiy OV, Zhang Y, Yuan H, Mo J, Ji C, Zhang B, Brayman TG, Lepsy C, Heath TG, Lai Y. Li N, et al. Among authors: lai y. Anal Biochem. 2008 Sep 15;380(2):211-22. doi: 10.1016/j.ab.2008.05.032. Epub 2008 May 27. Anal Biochem. 2008. PMID: 18558078

4

Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

Li N, Zhang Y, Hua F, Lai Y. Li N, et al. Among authors: lai y. Drug Metab Dispos. 2009 Jan;37(1):66-73. doi: 10.1124/dmd.108.023234. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832477

5

Saturation of multidrug-resistant protein 2 (mrp2/abcc2)-mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration.

Hu Y, Sampson KE, Heyde BR, Mandrell KM, Li N, Zutshi A, Lai Y. Hu Y, et al. Among authors: lai y. Drug Metab Dispos. 2009 Apr;37(4):841-6. doi: 10.1124/dmd.108.024059. Epub 2009 Jan 12. Drug Metab Dispos. 2009. PMID: 19139164

6

Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.

Yuan H, Li N, Lai Y. Yuan H, et al. Among authors: lai y. Drug Metab Dispos. 2009 Jul;37(7):1443-7. doi: 10.1124/dmd.108.026245. Epub 2009 Apr 16. Drug Metab Dispos. 2009. PMID: 19372225

7

Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.

Li N, Bi YA, Duignan DB, Lai Y. Li N, et al. Among authors: lai y. Mol Pharm. 2009 Jul-Aug;6(4):1180-9. doi: 10.1021/mp900044x. Mol Pharm. 2009. PMID: 19545175

8

Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.

Lai Y. Lai Y. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1175-87. doi: 10.1517/17425250903127234. Expert Opin Drug Metab Toxicol. 2009. PMID: 19611403 Review.

9

Evaluation of drug transporter interactions in drug discovery and development.

Lai Y, Sampson KE, Stevens JC. Lai Y, et al. Comb Chem High Throughput Screen. 2010 Feb;13(2):112-34. doi: 10.2174/138620710790596772. Comb Chem High Throughput Screen. 2010. PMID: 20053160 Review.

10

Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).

Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC. Lai Y, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. doi: 10.1124/jpet.110.170753. Epub 2010 Jun 2. J Pharmacol Exp Ther. 2010. PMID: 20519552 Clinical Trial.

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