Zhang H - Search Results

1

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.

Bi YA, Kimoto E, Sevidal S, Jones HM, Barton HA, Kempshall S, Whalen KM, Zhang H, Ji C, Fenner KS, El-Kattan AF, Lai Y. Bi YA, et al. Among authors: zhang h. Drug Metab Dispos. 2012 Jun;40(6):1085-92. doi: 10.1124/dmd.111.043489. Epub 2012 Mar 1. Drug Metab Dispos. 2012. PMID: 22381335 Review.

2

Development of a new permeability assay using low-efflux MDCKII cells.

Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ 3rd, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, Kempshall S, Fenner K, El-Kattan AF, Liston TE, Troutman MD. Di L, et al. Among authors: zhang h, zhang x. J Pharm Sci. 2011 Nov;100(11):4974-85. doi: 10.1002/jps.22674. Epub 2011 Jul 15. J Pharm Sci. 2011. PMID: 21766308

3

Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.

Kimoto E, Walsky R, Zhang H, Bi YA, Whalen KM, Yang YS, Linder C, Xiao Y, Iseki K, Fenner KS, El-Kattan AF, Lai Y. Kimoto E, et al. Among authors: zhang h. Drug Metab Dispos. 2012 Feb;40(2):407-11. doi: 10.1124/dmd.111.039297. Epub 2011 Oct 26. Drug Metab Dispos. 2012. PMID: 22031626

4

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

Varma MV, Gardner I, Steyn SJ, Nkansah P, Rotter CJ, Whitney-Pickett C, Zhang H, Di L, Cram M, Fenner KS, El-Kattan AF. Varma MV, et al. Among authors: zhang h. Mol Pharm. 2012 May 7;9(5):1199-212. doi: 10.1021/mp2004912. Epub 2012 Apr 26. Mol Pharm. 2012. PMID: 22489626

5

Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis.

Janiszewski J, Schneider R, Kapinos B, West M, Funk C, Federico J, Umland J, Piotrowski M, Mitchell W, Zhang H, Zelesky V, Gobey J, Whalen K, Liston T, Troutman M. Janiszewski J, et al. Among authors: zhang h. Bioanalysis. 2012 May;4(9):1039-56. doi: 10.4155/bio.12.87. Bioanalysis. 2012. PMID: 22612685

6

In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

Di L, Atkinson K, Orozco CC, Funk C, Zhang H, McDonald TS, Tan B, Lin J, Chang C, Obach RS. Di L, et al. Among authors: zhang h. Drug Metab Dispos. 2013 Dec;41(12):2018-23. doi: 10.1124/dmd.113.053322. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857891

7

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.

Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Fu C, et al. Among authors: zhang h. Drug Metab Dispos. 2013 Oct;41(10):1797-804. doi: 10.1124/dmd.113.053082. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857892

8

Quantitative targeted proteomics for membrane transporter proteins: method and application.

Qiu X, Zhang H, Lai Y. Qiu X, et al. Among authors: zhang h. AAPS J. 2014 Jul;16(4):714-26. doi: 10.1208/s12248-014-9607-6. Epub 2014 May 15. AAPS J. 2014. PMID: 24830943 Free PMC article. Review.

9

In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

Feng B, Varma MV, Costales C, Zhang H, Tremaine L. Feng B, et al. Among authors: zhang h. Expert Opin Drug Discov. 2014 Aug;9(8):873-90. doi: 10.1517/17460441.2014.922540. Epub 2014 May 24. Expert Opin Drug Discov. 2014. PMID: 24857286 Review.

10

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS. Bi YA, et al. Among authors: zhang h. AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. AAPS J. 2017. PMID: 28188574

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