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BLUEPRINT to decode the epigenetic signature written in blood.
Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Küppers R, Lehrach H, Lengauer T, Lernmark Å, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schübeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S. Adams D, et al. Among authors: spicuglia s. Nat Biotechnol. 2012 Mar 7;30(3):224-6. doi: 10.1038/nbt.2153. Nat Biotechnol. 2012. PMID: 22398613 No abstract available.
Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.
Cieslak A, Charbonnier G, Tesio M, Mathieu EL, Belhocine M, Touzart A, Smith C, Hypolite G, Andrieu GP, Martens JHA, Janssen-Megens E, Gut M, Gut I, Boissel N, Petit A, Puthier D, Macintyre E, Stunnenberg HG, Spicuglia S, Asnafi V. Cieslak A, et al. Among authors: spicuglia s. J Exp Med. 2020 Sep 7;217(9):e20192360. doi: 10.1084/jem.20192360. J Exp Med. 2020. PMID: 32667968 Free PMC article.
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Høiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG. Zhou H, et al. Among authors: spicuglia s. Mol Cell Biol. 2006 Apr;26(7):2728-35. doi: 10.1128/MCB.26.7.2728-2735.2006. Mol Cell Biol. 2006. PMID: 16537915 Free PMC article.
Dynamics of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.
Belhocine M, Simonin M, Abad Flores JD, Cieslak A, Manosalva I, Pradel L, Smith C, Mathieu EL, Charbonnier G, Martens JHA, Stunnenberg HG, Maqbool MA, Mikulasova A, Russell LJ, Rico D, Puthier D, Ferrier P, Asnafi V, Spicuglia S. Belhocine M, et al. Among authors: spicuglia s. Genome Res. 2022 Jul;32(7):1328-1342. doi: 10.1101/gr.266924.120. Epub 2021 Jun 23. Genome Res. 2022. PMID: 34162697 Free PMC article.
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.
Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A, Callens C, Lhermitte L, Baranger L, Radford-Weiss I, Grégoire MJ, Dombret H, Ifrah N, Spicuglia S, Romana S, Soulier J, Nadel B, Macintyre E, Asnafi V. Le Noir S, et al. Among authors: spicuglia s. Blood. 2012 Oct 18;120(16):3298-309. doi: 10.1182/blood-2012-04-425488. Epub 2012 Sep 4. Blood. 2012. PMID: 22948044 Free article.
RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.
Cieslak A, Le Noir S, Trinquand A, Lhermitte L, Franchini DM, Villarese P, Gon S, Bond J, Simonin M, Vanhille L, Reimann C, Verhoeyen E, Larghero J, Six E, Spicuglia S, André-Schmutz I, Langerak A, Nadel B, Macintyre E, Payet-Bornet D, Asnafi V. Cieslak A, et al. Among authors: spicuglia s. J Exp Med. 2014 Aug 25;211(9):1821-32. doi: 10.1084/jem.20132585. Epub 2014 Aug 18. J Exp Med. 2014. PMID: 25135298 Free PMC article.
An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, Sutton L, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V. Bond J, et al. Among authors: spicuglia s. Haematologica. 2016 Jun;101(6):732-40. doi: 10.3324/haematol.2015.141218. Epub 2016 Mar 4. Haematologica. 2016. PMID: 26944475 Free PMC article. Clinical Trial.
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