The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.
Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K.
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Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi: 10.1126/scitranslmed.aab1290.
Sci Transl Med. 2015.
PMID: 26203081
Free PMC article.