Slack RJ - Search Results

1

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation.

Procopiou PA, Ford AJ, Graves RH, Hall DA, Hodgson ST, Lacroix YM, Needham D, Slack RJ. Procopiou PA, et al. Among authors: slack rj. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2730-3. doi: 10.1016/j.bmcl.2012.02.104. Epub 2012 Mar 7. Bioorg Med Chem Lett. 2012. PMID: 22437117

2

The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.

Procopiou PA, Browning C, Buckley JM, Clark KL, Fechner L, Gore PM, Hancock AP, Hodgson ST, Holmes DS, Kranz M, Looker BE, Morriss KM, Parton DL, Russell LJ, Slack RJ, Sollis SL, Vile S, Watts CJ. Procopiou PA, et al. Among authors: slack rj. J Med Chem. 2011 Apr 14;54(7):2183-95. doi: 10.1021/jm1013874. Epub 2011 Mar 7. J Med Chem. 2011. PMID: 21381763

3

Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptors.

Slack RJ, Russell LJ, Hall DA, Luttmann MA, Ford AJ, Saunders KA, Hodgson ST, Connor HE, Browning C, Clark KL. Slack RJ, et al. Br J Pharmacol. 2011 Nov;164(6):1627-41. doi: 10.1111/j.1476-5381.2011.01285.x. Br J Pharmacol. 2011. PMID: 22022805 Free PMC article.

4

Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4.

Slack RJ, Hall DA. Slack RJ, et al. Br J Pharmacol. 2012 Jul;166(6):1774-92. doi: 10.1111/j.1476-5381.2012.01901.x. Br J Pharmacol. 2012. PMID: 22335621 Free PMC article.

5

Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists.

Procopiou PA, Browning C, Gore PM, Lynn SM, Richards SA, Slack RJ, Sollis SL. Procopiou PA, et al. Among authors: slack rj. Bioorg Med Chem. 2012 Oct 15;20(20):6097-108. doi: 10.1016/j.bmc.2012.08.032. Epub 2012 Aug 31. Bioorg Med Chem. 2012. PMID: 22985961

6

In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.

Slack RJ, Barrett VJ, Morrison VS, Sturton RG, Emmons AJ, Ford AJ, Knowles RG. Slack RJ, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):218-30. doi: 10.1124/jpet.112.198481. Epub 2012 Nov 6. J Pharmacol Exp Ther. 2013. PMID: 23131596

7

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H. Procopiou PA, et al. Among authors: slack rj. J Med Chem. 2013 Mar 14;56(5):1946-60. doi: 10.1021/jm301572h. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23409871

8

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists.

Ajram L, Begg M, Slack R, Cryan J, Hall D, Hodgson S, Ford A, Barnes A, Swieboda D, Mousnier A, Solari R. Ajram L, et al. Eur J Pharmacol. 2014 Apr 15;729(100):75-85. doi: 10.1016/j.ejphar.2014.02.007. Epub 2014 Feb 15. Eur J Pharmacol. 2014. PMID: 24534492 Free PMC article.

9

Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.

Slack RJ, Russell LJ, Barton NP, Weston C, Nalesso G, Thompson SA, Allen M, Chen YH, Barnes A, Hodgson ST, Hall DA. Slack RJ, et al. Pharmacol Res Perspect. 2013 Dec;1(2):e00019. doi: 10.1002/prp2.19. Epub 2013 Dec 30. Pharmacol Res Perspect. 2013. PMID: 25505571 Free PMC article.

10

2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

Shukla L, Ajram LA, Begg M, Evans B, Graves RH, Hodgson ST, Lynn SM, Miah AH, Percy JM, Procopiou PA, Richards SA, Slack RJ. Shukla L, et al. Among authors: slack rj. Eur J Med Chem. 2016 Jun 10;115:14-25. doi: 10.1016/j.ejmech.2016.02.058. Epub 2016 Feb 27. Eur J Med Chem. 2016. PMID: 26991939 Free article.

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