Baur JA - Search Results

1

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Lamming DW, et al. Among authors: baur ja. Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135. Science. 2012. PMID: 22461615 Free PMC article.

2

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Yang H, et al. Among authors: baur ja. Cell. 2007 Sep 21;130(6):1095-107. doi: 10.1016/j.cell.2007.07.035. Cell. 2007. PMID: 17889652 Free PMC article.

3

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. Price NL, et al. Among authors: baur ja. Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003. Cell Metab. 2012. PMID: 22560220 Free PMC article.

4

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA. Ye L, et al. Among authors: baur ja. Front Genet. 2012 Sep 11;3:177. doi: 10.3389/fgene.2012.00177. eCollection 2012. Front Genet. 2012. PMID: 22973301 Free PMC article.

5

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

Lamming DW, Ye L, Sabatini DM, Baur JA. Lamming DW, et al. Among authors: baur ja. J Clin Invest. 2013 Mar;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454761 Free PMC article. Review.

6

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Lamming DW, et al. Among authors: baur ja. Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7. Aging Cell. 2013. PMID: 23648089 Free PMC article.

7

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.

Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Ye L, et al. Among authors: baur ja. Aging (Albany NY). 2013 Jul;5(7):539-50. doi: 10.18632/aging.100576. Aging (Albany NY). 2013. PMID: 23929887 Free PMC article.

8

Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism.

Naidoo N, Davis JG, Zhu J, Yabumoto M, Singletary K, Brown M, Galante R, Agarwal B, Baur JA. Naidoo N, et al. Among authors: baur ja. Aging Cell. 2014 Feb;13(1):131-41. doi: 10.1111/acel.12158. Epub 2013 Nov 12. Aging Cell. 2014. PMID: 24102714 Free PMC article.

9

Rapamycin-induced metabolic defects are reversible in both lean and obese mice.

Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB. Liu Y, et al. Among authors: baur ja. Aging (Albany NY). 2014 Sep;6(9):742-54. doi: 10.18632/aging.100688. Aging (Albany NY). 2014. PMID: 25324470 Free PMC article.

10

Pharmacologic Means of Extending Lifespan.

Lamming DW, Sabatini DM, Baur JA. Lamming DW, et al. Among authors: baur ja. J Clin Exp Pathol. 2012 May 17;Suppl 4:7327. doi: 10.4172/2161-0681.S4-002. J Clin Exp Pathol. 2012. PMID: 25379357 Free PMC article. No abstract available.

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