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Therapeutic targeting of hyaluronan in the tumor stroma.
Kultti A, Li X, Jiang P, Thompson CB, Frost GI, Shepard HM. Kultti A, et al. Among authors: shepard hm. Cancers (Basel). 2012 Sep 6;4(3):873-903. doi: 10.3390/cancers4030873. Cancers (Basel). 2012. PMID: 24213471 Free PMC article.
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z. Kultti A, et al. Among authors: shepard hm. Biomed Res Int. 2014;2014:817613. doi: 10.1155/2014/817613. Epub 2014 Jul 24. Biomed Res Int. 2014. PMID: 25147816 Free PMC article.
Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression.
Li X, Shepard HM, Cowell JA, Zhao C, Osgood RJ, Rosengren S, Blouw B, Garrovillo SA, Pagel MD, Whatcott CJ, Han H, Von Hoff DD, Taverna DM, LaBarre MJ, Maneval DC, Thompson CB. Li X, et al. Among authors: shepard hm. Clin Cancer Res. 2018 Oct 1;24(19):4798-4807. doi: 10.1158/1078-0432.CCR-17-3284. Epub 2018 Jul 3. Clin Cancer Res. 2018. PMID: 30084839 Free PMC article.
Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.
Huang Z, Zhao C, Chen Y, Cowell JA, Wei G, Kultti A, Huang L, Thompson CB, Rosengren S, Frost GI, Shepard HM. Huang Z, et al. Among authors: shepard hm. J Immunol. 2014 Jun 1;192(11):5285-95. doi: 10.4049/jimmunol.1303060. Epub 2014 Apr 28. J Immunol. 2014. PMID: 24778442
PH20 is not expressed in murine CNS and oligodendrocyte precursor cells.
Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ. Marella M, et al. Among authors: shepard hm. Ann Clin Transl Neurol. 2017 Feb 23;4(3):191-211. doi: 10.1002/acn3.393. eCollection 2017 Mar. Ann Clin Transl Neurol. 2017. PMID: 28275653 Free PMC article.
95 results