Ng DS - Search Results

1

Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.

Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, Naples M, Baker C, Magomedova L, Tam J, Adeli K, Cummins CL, Connelly PW, Ng DS. Hager L, et al. Among authors: ng ds. J Biol Chem. 2012 Jun 8;287(24):20755-68. doi: 10.1074/jbc.M112.340919. Epub 2012 Apr 12. J Biol Chem. 2012. PMID: 22500017 Free PMC article.

2

Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis.

Ng DS, Maguire GF, Wylie J, Ravandi A, Xuan W, Ahmed Z, Eskandarian M, Kuksis A, Connelly PW. Ng DS, et al. J Biol Chem. 2002 Apr 5;277(14):11715-20. doi: 10.1074/jbc.M112320200. Epub 2002 Jan 24. J Biol Chem. 2002. PMID: 11809774 Free article.

3

Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance.

Ng DS, Xie C, Maguire GF, Zhu X, Ugwu F, Lam E, Connelly PW. Ng DS, et al. J Biol Chem. 2004 Feb 27;279(9):7636-42. doi: 10.1074/jbc.M309439200. Epub 2003 Dec 10. J Biol Chem. 2004. PMID: 14668345 Free article.

4

A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.

Zhu X, Herzenberg AM, Eskandarian M, Maguire GF, Scholey JW, Connelly PW, Ng DS. Zhu X, et al. Among authors: ng ds. Am J Pathol. 2004 Oct;165(4):1269-78. doi: 10.1016/S0002-9440(10)63386-X. Am J Pathol. 2004. PMID: 15466392 Free PMC article.

5

LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling.

Li L, Naples M, Song H, Yuan R, Ye F, Shafi S, Adeli K, Ng DS. Li L, et al. Among authors: ng ds. Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E587-94. doi: 10.1152/ajpendo.00278.2007. Epub 2007 Jun 5. Am J Physiol Endocrinol Metab. 2007. PMID: 17551001 Free article.

6

Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways.

Li L, Hossain MA, Sadat S, Hager L, Liu L, Tam L, Schroer S, Huogen L, Fantus IG, Connelly PW, Woo M, Ng DS. Li L, et al. Among authors: ng ds. J Biol Chem. 2011 May 20;286(20):17809-20. doi: 10.1074/jbc.M110.180893. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454561 Free PMC article.

7

Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS. Bashiri A, et al. Among authors: ng ds. Biochim Biophys Acta. 2016 Jul;1861(7):594-605. doi: 10.1016/j.bbalip.2016.04.005. Epub 2016 Apr 14. Biochim Biophys Acta. 2016. PMID: 27090939

8

Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism.

Song H, Zhu L, Picardo CM, Maguire G, Leung V, Connelly PW, Ng DS. Song H, et al. Among authors: ng ds. Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E17-E25. doi: 10.1152/ajpendo.00597.2004. Epub 2005 Aug 16. Am J Physiol Endocrinol Metab. 2006. PMID: 16105858 Free article.

9

Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia.

Ng DS, Chu T, Esposito B, Hui P, Connelly PW, Gross PL. Ng DS, et al. Cardiovasc Pathol. 2008 Jul-Aug;17(4):226-32. doi: 10.1016/j.carpath.2007.10.001. Epub 2007 Dec 3. Cardiovasc Pathol. 2008. PMID: 18402813

10

Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner.

Nesan D, Tavallaee G, Koh D, Bashiri A, Abdin R, Ng DS. Nesan D, et al. Among authors: ng ds. J Biol Chem. 2015 Dec 18;290(51):30514-29. doi: 10.1074/jbc.M115.676056. Epub 2015 Oct 22. J Biol Chem. 2015. PMID: 26494623 Free PMC article.

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