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Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.
Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG. Jain V, et al. Among authors: bacchetti p. J Infect Dis. 2013 Oct 15;208(8):1202-11. doi: 10.1093/infdis/jit311. Epub 2013 Jul 12. J Infect Dis. 2013. PMID: 23852127 Free PMC article.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S. Josefsson L, et al. Among authors: bacchetti p. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4987-96. doi: 10.1073/pnas.1308313110. Epub 2013 Nov 25. Proc Natl Acad Sci U S A. 2013. PMID: 24277811 Free PMC article. Clinical Trial.
Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. von Stockenstrom S, et al. Among authors: bacchetti p. J Infect Dis. 2015 Aug 15;212(4):596-607. doi: 10.1093/infdis/jiv092. Epub 2015 Feb 23. J Infect Dis. 2015. PMID: 25712966 Free PMC article.
Differential persistence of transmitted HIV-1 drug resistance mutation classes.
Jain V, Sucupira MC, Bacchetti P, Hartogensis W, Diaz RS, Kallas EG, Janini LM, Liegler T, Pilcher CD, Grant RM, Cortes R, Deeks SG, Hecht FM. Jain V, et al. Among authors: bacchetti p. J Infect Dis. 2011 Apr 15;203(8):1174-81. doi: 10.1093/infdis/jiq167. J Infect Dis. 2011. PMID: 21451005 Free PMC article.
Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.
Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR. Khoury G, et al. Among authors: bacchetti p. J Infect Dis. 2017 Mar 15;215(6):911-919. doi: 10.1093/infdis/jix039. J Infect Dis. 2017. PMID: 28453847 Free PMC article.
Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S. Lee E, et al. Among authors: bacchetti p. J Virol. 2020 Jan 17;94(3):e01270-19. doi: 10.1128/JVI.01270-19. Print 2020 Jan 17. J Virol. 2020. PMID: 31723024 Free PMC article.
Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.
Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR. Anderson JL, et al. Among authors: bacchetti p. J Infect Dis. 2020 Feb 18;221(5):744-755. doi: 10.1093/infdis/jiz509. J Infect Dis. 2020. PMID: 31796951 Free PMC article.
Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion.
Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon DF, Karlsson AC. Perez CL, et al. Among authors: bacchetti p. AIDS Res Hum Retroviruses. 2013 Mar;29(3):602-12. doi: 10.1089/AID.2012.0171. Epub 2013 Jan 8. AIDS Res Hum Retroviruses. 2013. PMID: 23140171 Free PMC article.
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N. Fromentin R, et al. Among authors: bacchetti p. PLoS Pathog. 2016 Jul 14;12(7):e1005761. doi: 10.1371/journal.ppat.1005761. eCollection 2016 Jul. PLoS Pathog. 2016. PMID: 27415008 Free PMC article.
348 results