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Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.
Hu E, Ma J, Biorn C, Lester-Zeiner D, Cho R, Rumfelt S, Kunz RK, Nixey T, Michelsen K, Miller S, Shi J, Wong J, Hill Della Puppa G, Able J, Talreja S, Hwang DR, Hitchcock SA, Porter A, Immke D, Allen JR, Treanor J, Chen H. Hu E, et al. Among authors: wong j. J Med Chem. 2012 May 24;55(10):4776-87. doi: 10.1021/jm3002372. Epub 2012 May 11. J Med Chem. 2012. PMID: 22548439
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
Chen H, Lester-Zeiner D, Shi J, Miller S, Glaus C, Hu E, Chen N, Able J, Biorn C, Wong J, Ma J, Michelsen K, Hill Della Puppa G, Kazules T, Dou HH, Talreja S, Zhao X, Chen A, Rumfelt S, Kunz RK, Ye H, Thiel OR, Williamson T, Davis C, Porter A, Immke D, Allen JR, Treanor J. Chen H, et al. Among authors: wong j. J Pharmacol Exp Ther. 2015 Feb;352(2):327-37. doi: 10.1124/jpet.114.220517. Epub 2014 Dec 11. J Pharmacol Exp Ther. 2015. PMID: 25502803
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bui M, Hao X, Shin Y, Cardozo M, He X, Henne K, Suchomel J, McCarter J, McGee LR, San Miguel T, Medina JC, Mohn D, Tran T, Wannberg S, Wong J, Wong S, Zalameda L, Metz D, Cushing TD. Bui M, et al. Among authors: wong s, wong j. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1104-9. doi: 10.1016/j.bmcl.2015.01.001. Epub 2015 Jan 17. Bioorg Med Chem Lett. 2015. PMID: 25666823
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Bumpers QA, Pipal RW, Benz-Weeden AM, Brewster JT 2nd, Cook A, Crooks AL, Cruz C, Dwulet NC, Gaudino JJ, Golec D, Harrison JA, Hartley DP, Hassanien SH, Hicken EJ, Kahn D, Laird ER, Lemieux C, Lewandowski N, McCown J, McDonald MG, McNulty O, Mou TC, Nguyen P, Oko L, Opie LP, Otten J, Peck SC, Polites VC, Randall SD, Rosen RZ, Savechenkov P, Simpson H, Singh A, Sparks D, Wickersham K, Wollenberg L, Wong CE, Wong J, Wu WI, Elsayed MSA, Hinklin RJ, Tang TP. Bumpers QA, et al. Among authors: wong j, wong ce. J Med Chem. 2024 Aug 22;67(16):14466-14477. doi: 10.1021/acs.jmedchem.4c01232. Epub 2024 Aug 1. J Med Chem. 2024. PMID: 39088797
Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA.
Hicken EJ, Brown K, Dwulet NC, Gaudino JJ, Hansen EP, Hartley DP, Kowalski JP, Laird ER, Lazzara NC, Li B, Mou TC, Mutryn MF, Oko L, Pajk S, Pipal RW, Rosen RZ, Shelp R, Singh A, Wang J, Wise CE, Wong C, Wong JY. Hicken EJ, et al. Among authors: wong jy, wong c. J Med Chem. 2024 Jun 13;67(11):9759-9771. doi: 10.1021/acs.jmedchem.4c00978. Epub 2024 May 31. J Med Chem. 2024. PMID: 38820338
PFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos.
Lion AT, Bodine SM, McCutcheon KR, Ghogale M, Chandragiri S, Abayawardena D, Shrestha BD, Descoteaux A, Alvarez K, Balkman JA, Cocke B, Wikramanayake AH, Schlezinger J, Wong JY, Prakash VN, Bradham CA. Lion AT, et al. Among authors: wong jy. bioRxiv [Preprint]. 2024 Nov 21:2024.11.21.624751. doi: 10.1101/2024.11.21.624751. bioRxiv. 2024. PMID: 39605628 Free PMC article. Preprint.
Dengue.
Adams LE, Wong JM, Paz-Bailey G. Adams LE, et al. Among authors: wong jm. JAMA. 2024 Nov 27. doi: 10.1001/jama.2024.21094. Online ahead of print. JAMA. 2024. PMID: 39602174
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