Ratan RR - Search Results

1

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.

Sleiman SF, Berlin J, Basso M, Karuppagounder SS, Rohr J, Ratan RR. Sleiman SF, et al. Among authors: ratan rr. Pharmaceuticals (Basel). 2011 Aug 22;4(8):1183-1195. doi: 10.3390/ph4081183. Pharmaceuticals (Basel). 2011. PMID: 22582024 Free PMC article.

2

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Sleiman SF, et al. Among authors: ratan rr. Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345. Expert Opin Investig Drugs. 2009. PMID: 19388875 Free PMC article. Review.

3

HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

Niatsetskaya Z, Basso M, Speer RE, McConoughey SJ, Coppola G, Ma TC, Ratan RR. Niatsetskaya Z, et al. Among authors: ratan rr. Antioxid Redox Signal. 2010 Apr;12(4):435-43. doi: 10.1089/ars.2009.2800. Antioxid Redox Signal. 2010. PMID: 19659431 Free PMC article.

4

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.

Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. Smirnova NA, et al. Among authors: ratan rr. Chem Biol. 2010 Apr 23;17(4):380-91. doi: 10.1016/j.chembiol.2010.03.008. Chem Biol. 2010. PMID: 20416509 Free PMC article.

5

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR. McConoughey SJ, et al. Among authors: ratan rr. EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084. EMBO Mol Med. 2010. PMID: 20665636 Free PMC article.

6

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR. Sleiman SF, et al. Among authors: ratan rr. J Neurosci. 2011 May 4;31(18):6858-70. doi: 10.1523/JNEUROSCI.0710-11.2011. J Neurosci. 2011. PMID: 21543616 Free PMC article.

7

Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG. Smirnova NA, et al. Among authors: ratan rr. Chem Biol. 2011 Jun 24;18(6):752-65. doi: 10.1016/j.chembiol.2011.03.013. Chem Biol. 2011. PMID: 21700211 Free PMC article.

8

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

Karuppagounder SS, Ratan RR. Karuppagounder SS, et al. Among authors: ratan rr. J Cereb Blood Flow Metab. 2012 Jul;32(7):1347-61. doi: 10.1038/jcbfm.2012.28. Epub 2012 Mar 14. J Cereb Blood Flow Metab. 2012. PMID: 22415525 Free PMC article. Review.

9

Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.

Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR. Basso M, et al. Among authors: ratan rr. J Neurosci. 2012 May 9;32(19):6561-9. doi: 10.1523/JNEUROSCI.3353-11.2012. J Neurosci. 2012. PMID: 22573678 Free PMC article.

10

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR. Speer RE, et al. Among authors: ratan rr. Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Free Radic Biol Med. 2013. PMID: 23376032 Free PMC article. Review.

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