Holland WL - Search Results

1

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.

Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD. Zhang QJ, et al. Among authors: holland wl. Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14. Diabetes. 2012. PMID: 22586587 Free PMC article.

2

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.

Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA. Chavez JA, et al. Among authors: holland wl. J Biol Chem. 2005 May 20;280(20):20148-53. doi: 10.1074/jbc.M412769200. Epub 2005 Mar 17. J Biol Chem. 2005. PMID: 15774472 Free article.

3

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.

Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA. Holland WL, et al. Cell Metab. 2007 Mar;5(3):167-79. doi: 10.1016/j.cmet.2007.01.002. Cell Metab. 2007. PMID: 17339025 Free article.

4

Lipid mediators of insulin resistance.

Holland WL, Knotts TA, Chavez JA, Wang LP, Hoehn KL, Summers SA. Holland WL, et al. Nutr Rev. 2007 Jun;65(6 Pt 2):S39-46. doi: 10.1111/j.1753-4887.2007.tb00327.x. Nutr Rev. 2007. PMID: 17605313 Review.

5

Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

Holland WL, Summers SA. Holland WL, et al. Endocr Rev. 2008 Jun;29(4):381-402. doi: 10.1210/er.2007-0025. Epub 2008 May 1. Endocr Rev. 2008. PMID: 18451260 Free PMC article. Review.

6

Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ. Fujii N, et al. Among authors: holland wl. Diabetes. 2008 Nov;57(11):2958-66. doi: 10.2337/db07-1187. Epub 2008 Aug 26. Diabetes. 2008. PMID: 18728234 Free PMC article.

7

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA. Holland WL, et al. J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1. J Clin Invest. 2011. PMID: 21490391 Free PMC article.

8

Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis.

Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA. Bikman BT, et al. Among authors: holland wl. J Biol Chem. 2012 May 18;287(21):17426-17437. doi: 10.1074/jbc.M112.359950. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474281 Free PMC article.

9

Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.

Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. Boudina S, et al. Among authors: holland wl. Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17. Endocrinology. 2012. PMID: 22510273 Free PMC article.

10

Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.

Goodspeed D, Seferovic MD, Holland W, Mcknight RA, Summers SA, Branch DW, Lane RH, Aagaard KM. Goodspeed D, et al. FASEB J. 2015 Mar;29(3):807-19. doi: 10.1096/fj.14-259614. Epub 2014 Nov 13. FASEB J. 2015. PMID: 25395450 Free PMC article.

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