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PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W. Ahuja EG, et al. Among authors: janning p. J Am Chem Soc. 2008 Dec 17;130(50):17053-61. doi: 10.1021/ja806325k. J Am Chem Soc. 2008. PMID: 19053436
Identification of Ustilago maydis Aurora kinase as a novel antifungal target.
Tückmantel S, Greul JN, Janning P, Brockmeyer A, Grütter C, Simard JR, Gutbrod O, Beck ME, Tietjen K, Rauh D, Schreier PH. Tückmantel S, et al. Among authors: janning p. ACS Chem Biol. 2011 Sep 16;6(9):926-33. doi: 10.1021/cb200112y. Epub 2011 Jun 20. ACS Chem Biol. 2011. PMID: 21671622
Covalent-Allosteric Kinase Inhibitors.
Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, Rauh D. Weisner J, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10313-6. doi: 10.1002/anie.201502142. Epub 2015 Jun 25. Angew Chem Int Ed Engl. 2015. PMID: 26110718
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, Hardick J, Gontla R, Scheinpflug R, Czodrowski P, Janning P, Depta L, Quambusch L, Müller MP, Engels B, Rauh D. Uhlenbrock N, et al. Among authors: janning p. Chem Sci. 2019 Feb 13;10(12):3573-3585. doi: 10.1039/c8sc05212c. eCollection 2019 Mar 28. Chem Sci. 2019. PMID: 30996949 Free PMC article.
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.
Goebel L, Kirschner T, Koska S, Rai A, Janning P, Maffini S, Vatheuer H, Czodrowski P, Goody RS, Müller MP, Rauh D. Goebel L, et al. Among authors: janning p. Elife. 2023 Mar 27;12:e82184. doi: 10.7554/eLife.82184. Elife. 2023. PMID: 36972177 Free PMC article.
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.
Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, Triola G, Brockmeyer A, Janning P, Böttcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H. Rusch M, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9838-42. doi: 10.1002/anie.201102967. Epub 2011 Sep 9. Angew Chem Int Ed Engl. 2011. PMID: 21905186
Small-Molecule Target Engagement in Cells.
Schürmann M, Janning P, Ziegler S, Waldmann H. Schürmann M, et al. Among authors: janning p. Cell Chem Biol. 2016 Apr 21;23(4):435-41. doi: 10.1016/j.chembiol.2016.03.008. Epub 2016 Mar 31. Cell Chem Biol. 2016. PMID: 27049669 Free article. Review.
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