Aiuti A - Search Results

1

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.

Sauer AV, Morbach H, Brigida I, Ng YS, Aiuti A, Meffre E. Sauer AV, et al. Among authors: aiuti a. J Clin Invest. 2012 Jun;122(6):2141-52. doi: 10.1172/JCI61788. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622038 Free PMC article. Clinical Trial.

2

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning.

Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellaro A, Morecki S, Andolfi G, Tabucchi A, Carlucci F, Marinello E, Cattaneo F, Vai S, Servida P, Miniero R, Roncarolo MG, Bordignon C. Aiuti A, et al. Science. 2002 Jun 28;296(5577):2410-3. doi: 10.1126/science.1070104. Science. 2002. PMID: 12089448 Clinical Trial.

3

Advances in gene therapy for ADA-deficient SCID.

Aiuti A. Aiuti A. Curr Opin Mol Ther. 2002 Oct;4(5):515-22. Curr Opin Mol Ther. 2002. PMID: 12435054 Review.

4

Gene therapy for adenosine deaminase deficiency.

Aiuti A, Ficara F, Cattaneo F, Bordignon C, Roncarolo MG. Aiuti A, et al. Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):461-6. doi: 10.1097/00130832-200312000-00007. Curr Opin Allergy Clin Immunol. 2003. PMID: 14612670 Review.

5

Gene therapy for adenosine-deaminase-deficient severe combined immunodeficiency.

Aiuti A. Aiuti A. Best Pract Res Clin Haematol. 2004 Sep;17(3):505-16. doi: 10.1016/j.beha.2004.05.012. Best Pract Res Clin Haematol. 2004. PMID: 15498720 Review.

6

IL-3 or IL-7 increases ex vivo gene transfer efficiency in ADA-SCID BM CD34+ cells while maintaining in vivo lymphoid potential.

Ficara F, Superchi DB, Hernández RJ, Mocchetti C, Carballido-Perrig N, Andolfi G, Deola S, Colombo A, Bordignon C, Carballido JM, Roncarolo MG, Aiuti A. Ficara F, et al. Among authors: aiuti a. Mol Ther. 2004 Dec;10(6):1096-108. doi: 10.1016/j.ymthe.2004.08.014. Mol Ther. 2004. PMID: 15564141 Free article.

7

Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.

Dupré L, Marangoni F, Scaramuzza S, Trifari S, Hernández RJ, Aiuti A, Naldini L, Roncarolo MG. Dupré L, et al. Among authors: aiuti a. Hum Gene Ther. 2006 Mar;17(3):303-13. doi: 10.1089/hum.2006.17.303. Hum Gene Ther. 2006. PMID: 16544979

8

Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects.

Mortellaro A, Hernandez RJ, Guerrini MM, Carlucci F, Tabucchi A, Ponzoni M, Sanvito F, Doglioni C, Di Serio C, Biasco L, Follenzi A, Naldini L, Bordignon C, Roncarolo MG, Aiuti A. Mortellaro A, et al. Among authors: aiuti a. Blood. 2006 Nov 1;108(9):2979-88. doi: 10.1182/blood-2006-05-023507. Epub 2006 Jul 11. Blood. 2006. PMID: 16835374 Free article.

9

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy.

Aiuti A, Cassani B, Andolfi G, Mirolo M, Biasco L, Recchia A, Urbinati F, Valacca C, Scaramuzza S, Aker M, Slavin S, Cazzola M, Sartori D, Ambrosi A, Di Serio C, Roncarolo MG, Mavilio F, Bordignon C. Aiuti A, et al. J Clin Invest. 2007 Aug;117(8):2233-40. doi: 10.1172/JCI31666. J Clin Invest. 2007. PMID: 17671653 Free PMC article. Clinical Trial.

10

Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.

Cassani B, Mirolo M, Cattaneo F, Benninghoff U, Hershfield M, Carlucci F, Tabucchi A, Bordignon C, Roncarolo MG, Aiuti A. Cassani B, et al. Among authors: aiuti a. Blood. 2008 Apr 15;111(8):4209-19. doi: 10.1182/blood-2007-05-092429. Epub 2008 Jan 24. Blood. 2008. PMID: 18218852 Free PMC article. Clinical Trial.

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