Brendel C - Search Results

1

Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing.

Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y. Knight S, et al. Among authors: brendel c. J Virol. 2012 Sep;86(17):9088-95. doi: 10.1128/JVI.00485-12. Epub 2012 Jun 13. J Virol. 2012. PMID: 22696657 Free PMC article.

2

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. Pfaff N, et al. Among authors: brendel c. Stem Cells. 2013 Mar;31(3):488-99. doi: 10.1002/stem.1316. Stem Cells. 2013. PMID: 23307570

3

Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.

Brendel C, Rothe M, Santilli G, Charrier S, Stein S, Kunkel H, Abriss D, Müller-Kuller U, Gaspar B, Modlich U, Galy A, Schambach A, Thrasher AJ, Grez M. Brendel C, et al. Hum Gene Ther Clin Dev. 2018 Jun;29(2):69-79. doi: 10.1089/humc.2017.245. Epub 2018 Apr 17. Hum Gene Ther Clin Dev. 2018. PMID: 29664709

4

Differential Transgene Silencing of Myeloid-Specific Promoters in the AAVS1 Safe Harbor Locus of Induced Pluripotent Stem Cell-Derived Myeloid Cells.

Klatt D, Cheng E, Hoffmann D, Santilli G, Thrasher AJ, Brendel C, Schambach A. Klatt D, et al. Among authors: brendel c. Hum Gene Ther. 2020 Feb;31(3-4):199-210. doi: 10.1089/hum.2019.194. Epub 2020 Jan 23. Hum Gene Ther. 2020. PMID: 31773990 Free PMC article.

5

Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.

Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ. Santilli G, et al. Among authors: brendel c. Mol Ther. 2011 Jan;19(1):122-32. doi: 10.1038/mt.2010.226. Epub 2010 Oct 26. Mol Ther. 2011. PMID: 20978475 Free PMC article.

6

Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.

Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M. Brendel C, et al. Gene Ther. 2012 Oct;19(10):1018-29. doi: 10.1038/gt.2011.167. Epub 2011 Nov 10. Gene Ther. 2012. PMID: 22071971

7

Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.

Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Kaufmann KB, et al. Among authors: brendel c. Mol Ther. 2013 Mar;21(3):648-61. doi: 10.1038/mt.2012.249. Epub 2012 Dec 4. Mol Ther. 2013. PMID: 23207695 Free PMC article.

8

A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.

Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M. Müller-Kuller U, et al. Among authors: brendel c. Nucleic Acids Res. 2015 Feb 18;43(3):1577-92. doi: 10.1093/nar/gkv019. Epub 2015 Jan 20. Nucleic Acids Res. 2015. PMID: 25605798 Free PMC article.

9

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.

Vets S, De Rijck J, Brendel C, Grez M, Bushman F, Debyser Z, Gijsbers R. Vets S, et al. Among authors: brendel c. Mol Ther Nucleic Acids. 2013 Mar 5;2(3):e77. doi: 10.1038/mtna.2013.4. Mol Ther Nucleic Acids. 2013. PMID: 23462964 Free PMC article.

10

Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions.

Weisser M, Demel UM, Stein S, Chen-Wichmann L, Touzot F, Santilli G, Sujer S, Brendel C, Siler U, Cavazzana M, Thrasher AJ, Reichenbach J, Essers MAG, Schwäble J, Grez M. Weisser M, et al. Among authors: brendel c. J Allergy Clin Immunol. 2016 Jul;138(1):219-228.e9. doi: 10.1016/j.jaci.2015.11.028. Epub 2016 Feb 4. J Allergy Clin Immunol. 2016. PMID: 26853280

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