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Physical confinement alters tumor cell adhesion and migration phenotypes.
Balzer EM, Tong Z, Paul CD, Hung WC, Stroka KM, Boggs AE, Martin SS, Konstantopoulos K. Balzer EM, et al. Among authors: boggs ae. FASEB J. 2012 Oct;26(10):4045-56. doi: 10.1096/fj.12-211441. Epub 2012 Jun 15. FASEB J. 2012. PMID: 22707566 Free PMC article.
The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.
Thompson KN, Whipple RA, Yoon JR, Lipsky M, Charpentier MS, Boggs AE, Chakrabarti KR, Bhandary L, Hessler LK, Martin SS, Vitolo MI. Thompson KN, et al. Among authors: boggs ae. Oncotarget. 2015 Nov 3;6(34):35231-46. doi: 10.18632/oncotarget.6159. Oncotarget. 2015. PMID: 26497685 Free PMC article.
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