Brazzolotto X - Search Results

1

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.

Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F. Brazzolotto X, et al. FEBS J. 2012 Aug;279(16):2905-16. doi: 10.1111/j.1742-4658.2012.08672.x. Epub 2012 Jul 12. FEBS J. 2012. PMID: 22726956 Free article.

2

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F. Trovaslet-Leroy M, et al. Among authors: brazzolotto x. Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041. Epub 2011 Jun 12. Toxicol Lett. 2011. PMID: 21683774

3

Progress in the development of enzyme-based nerve agent bioscavengers.

Nachon F, Brazzolotto X, Trovaslet M, Masson P. Nachon F, et al. Among authors: brazzolotto x. Chem Biol Interact. 2013 Dec 5;206(3):536-44. doi: 10.1016/j.cbi.2013.06.012. Epub 2013 Jun 26. Chem Biol Interact. 2013. PMID: 23811386 Review.

4

Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.

Dighe SN, Deora GS, De la Mora E, Nachon F, Chan S, Parat MO, Brazzolotto X, Ross BP. Dighe SN, et al. Among authors: brazzolotto x. J Med Chem. 2016 Aug 25;59(16):7683-9. doi: 10.1021/acs.jmedchem.6b00356. Epub 2016 Jul 26. J Med Chem. 2016. PMID: 27405689

5

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.

Košak U, Knez D, Coquelle N, Brus B, Pišlar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S. Košak U, et al. Among authors: brazzolotto x. Bioorg Med Chem. 2017 Jan 15;25(2):633-645. doi: 10.1016/j.bmc.2016.11.032. Epub 2016 Nov 19. Bioorg Med Chem. 2017. PMID: 27908752

6

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

Košak U, Brus B, Knez D, Šink R, Žakelj S, Trontelj J, Pišlar A, Šlenc J, Gobec M, Živin M, Tratnjek L, Perše M, Sałat K, Podkowa A, Filipek B, Nachon F, Brazzolotto X, Więckowska A, Malawska B, Stojan J, Raščan IM, Kos J, Coquelle N, Colletier JP, Gobec S. Košak U, et al. Among authors: brazzolotto x. Sci Rep. 2016 Dec 21;6:39495. doi: 10.1038/srep39495. Sci Rep. 2016. PMID: 28000737 Free PMC article.

7

Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development.

Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F. Brazzolotto X, et al. Molecules. 2017 Oct 27;22(11):1828. doi: 10.3390/molecules22111828. Molecules. 2017. PMID: 29077024 Free PMC article.

8

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

Rosenberry TL, Brazzolotto X, Macdonald IR, Wandhammer M, Trovaslet-Leroy M, Darvesh S, Nachon F. Rosenberry TL, et al. Among authors: brazzolotto x. Molecules. 2017 Nov 29;22(12):2098. doi: 10.3390/molecules22122098. Molecules. 2017. PMID: 29186056 Free PMC article.

9

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.

Košak U, Brus B, Knez D, Žakelj S, Trontelj J, Pišlar A, Šink R, Jukič M, Živin M, Podkowa A, Nachon F, Brazzolotto X, Stojan J, Kos J, Coquelle N, Sałat K, Colletier JP, Gobec S. Košak U, et al. Among authors: brazzolotto x. J Med Chem. 2018 Jan 11;61(1):119-139. doi: 10.1021/acs.jmedchem.7b01086. Epub 2017 Dec 22. J Med Chem. 2018. PMID: 29227101

10

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.

Knez D, Coquelle N, Pišlar A, Žakelj S, Jukič M, Sova M, Mravljak J, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S. Knez D, et al. Among authors: brazzolotto x. Eur J Med Chem. 2018 Aug 5;156:598-617. doi: 10.1016/j.ejmech.2018.07.033. Epub 2018 Jul 19. Eur J Med Chem. 2018. PMID: 30031971

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