Wakabayashi K - Search Results

1

Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPARγ modulators.

Furukawa A, Arita T, Fukuzaki T, Mori M, Honda T, Satoh S, Matsui Y, Wakabayashi K, Hayashi S, Nakamura K, Araki K, Kuroha M, Tanaka J, Wakimoto S, Suzuki O, Ohsumi J. Furukawa A, et al. Among authors: wakabayashi k. Eur J Med Chem. 2012 Aug;54:522-33. doi: 10.1016/j.ejmech.2012.05.040. Epub 2012 Jun 7. Eur J Med Chem. 2012. PMID: 22727448

2

Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.

Furukawa A, Arita T, Satoh S, Wakabayashi K, Hayashi S, Matsui Y, Araki K, Kuroha M, Ohsumi J. Furukawa A, et al. Among authors: wakabayashi k. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2095-8. doi: 10.1016/j.bmcl.2010.02.073. Epub 2010 Feb 20. Bioorg Med Chem Lett. 2010. PMID: 20219371

3

Pharmacology and in vitro profiling of a novel peroxisome proliferator-activated receptor γ ligand, Cerco-A.

Wakabayashi K, Hayashi S, Matsui Y, Matsumoto T, Furukawa A, Kuroha M, Tanaka N, Inaba T, Kanda S, Tanaka J, Okuyama R, Wakimoto S, Ogata T, Araki K, Ohsumi J. Wakabayashi K, et al. Biol Pharm Bull. 2011;34(7):1094-104. doi: 10.1248/bpb.34.1094. Biol Pharm Bull. 2011. PMID: 21720019 Free article.

4

Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists.

Furukawa A, Arita T, Fukuzaki T, Satoh S, Mori M, Honda T, Matsui Y, Wakabayashi K, Hayashi S, Araki K, Ohsumi J. Furukawa A, et al. Among authors: wakabayashi k. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1348-51. doi: 10.1016/j.bmcl.2011.12.066. Epub 2011 Dec 16. Bioorg Med Chem Lett. 2012. PMID: 22225641

5

Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists.

Matsui Y, Yamaguchi T, Yamazaki T, Yoshida M, Arai M, Terasaka N, Honzumi S, Wakabayashi K, Hayashi S, Nakai D, Hanzawa H, Tamaki K. Matsui Y, et al. Among authors: wakabayashi k. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3914-20. doi: 10.1016/j.bmcl.2015.07.047. Epub 2015 Jul 23. Bioorg Med Chem Lett. 2015. PMID: 26238323

6

Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.

Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T. Ito S, et al. Among authors: wakabayashi k. J Biol Chem. 2002 Feb 22;277(8):6631-6. doi: 10.1074/jbc.M106525200. Epub 2001 Nov 30. J Biol Chem. 2002. PMID: 11733492 Free article.

7

Discovery of a Novel Class of ERRα Agonists.

Shinozuka T, Ito S, Kimura T, Izumi M, Wakabayashi K. Shinozuka T, et al. Among authors: wakabayashi k. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821. doi: 10.1021/acsmedchemlett.1c00100. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055231 Free PMC article.

8

A novel compound, R-138329, increases plasma HDL cholesterol via inhibition of scavenger receptor BI-mediated selective lipid uptake.

Nishizawa T, Kitayama K, Wakabayashi K, Yamada M, Uchiyama M, Abe K, Ubukata N, Inaba T, Oda T, Amemiya Y. Nishizawa T, et al. Among authors: wakabayashi k. Atherosclerosis. 2007 Oct;194(2):300-8. doi: 10.1016/j.atherosclerosis.2006.10.025. Epub 2006 Dec 12. Atherosclerosis. 2007. PMID: 17166497

9

Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.

Fujita-Sato S, Ito S, Isobe T, Ohyama T, Wakabayashi K, Morishita K, Ando O, Isono F. Fujita-Sato S, et al. Among authors: wakabayashi k. J Biol Chem. 2011 Sep 9;286(36):31409-17. doi: 10.1074/jbc.M111.254003. Epub 2011 Jul 6. J Biol Chem. 2011. PMID: 21733845 Free PMC article.

10

Blockade of scavenger receptor class B type I raises high density lipoprotein cholesterol levels but exacerbates atherosclerotic lesion formation in apolipoprotein E deficient mice.

Kitayama K, Nishizawa T, Abe K, Wakabayashi K, Oda T, Inaba T, Amemiya Y. Kitayama K, et al. Among authors: wakabayashi k. J Pharm Pharmacol. 2006 Dec;58(12):1629-38. doi: 10.1211/jpp.58.12.0010. J Pharm Pharmacol. 2006. PMID: 17331327

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