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Page 1
Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: wakimoto s. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. doi: 10.1016/j.bmc.2018.09.005. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30220602
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: wakimoto s. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Uto Y, Ogata T, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Konishi M, Okuyama R, Kurikawa N, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Among authors: wakimoto s. Bioorg Med Chem Lett. 2010 Jan 1;20(1):341-5. doi: 10.1016/j.bmcl.2009.10.101. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19926281
Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, Ogata T, Yamada M, Deguchi T, Konishi M, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Among authors: wakimoto s. Eur J Med Chem. 2010 Nov;45(11):4788-96. doi: 10.1016/j.ejmech.2010.07.044. Epub 2010 Aug 4. Eur J Med Chem. 2010. PMID: 20801551
Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Matsui Y, Wakimoto S, Ogata T, Araki K, Sawamura R, Watanabe N, Mori M, Tanaka J. Shinozuka T, et al. Among authors: wakimoto s. ACS Med Chem Lett. 2019 Feb 26;10(3):358-362. doi: 10.1021/acsmedchemlett.8b00645. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891140 Free PMC article.
Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].
Uto Y, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Ogata T, Deguchi T, Yamada M, Watanabe N, Konishi M, Kurikawa N, Takagi T, Wakimoto S, Kono K, Ohsumi J. Uto Y, et al. Among authors: wakimoto s. Bioorg Med Chem Lett. 2010 Jan 15;20(2):746-54. doi: 10.1016/j.bmcl.2009.11.043. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 20006498
48 results