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Artesunate enhances the antibacterial effect of {beta}-lactam antibiotics against Escherichia coli by increasing antibiotic accumulation via inhibition of the multidrug efflux pump system AcrAB-TolC.
Li B, Yao Q, Pan XC, Wang N, Zhang R, Li J, Ding G, Liu X, Wu C, Ran D, Zheng J, Zhou H. Li B, et al. Among authors: liu x. J Antimicrob Chemother. 2011 Apr;66(4):769-77. doi: 10.1093/jac/dkr017. Epub 2011 Feb 9. J Antimicrob Chemother. 2011. PMID: 21393180
Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin.
Jiang W, Li B, Zheng X, Liu X, Cen Y, Li J, Pan X, Cao H, Zheng J, Zhou H. Jiang W, et al. Among authors: liu x. Int Immunopharmacol. 2011 Aug;11(8):1065-73. doi: 10.1016/j.intimp.2011.02.028. Epub 2011 Mar 21. Int Immunopharmacol. 2011. PMID: 21396483
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