Frédérick R - Search Results

1

Novel trisubstituted harmine derivatives with original in vitro anticancer activity.

Frédérick R, Bruyère C, Vancraeynest C, Reniers J, Meinguet C, Pochet L, Backlund A, Masereel B, Kiss R, Wouters J. Frédérick R, et al. J Med Chem. 2012 Jul 26;55(14):6489-501. doi: 10.1021/jm300542e. Epub 2012 Jul 18. J Med Chem. 2012. PMID: 22770529 Free article.

2

Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.

Ooms F, Frédérick R, Durant F, Petzer JP, Castagnoli N, Van der Schyf CJ, Wouters J. Ooms F, et al. Among authors: frederick r. Bioorg Med Chem Lett. 2003 Jan 6;13(1):69-73. doi: 10.1016/s0960-894x(02)00838-7. Bioorg Med Chem Lett. 2003. PMID: 12467619

3

Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors.

Frédérick R, Norberg B, Durant F, Ooms F, Wouters J. Frédérick R, et al. Acta Crystallogr C. 2004 Sep;60(Pt 9):o623-6. doi: 10.1107/S0108270104014660. Epub 2004 Aug 11. Acta Crystallogr C. 2004. PMID: 15345837

4

Coumarin and isocoumarin as serine protease inhibitors.

Pochet L, Frédérick R, Masereel B. Pochet L, et al. Among authors: frederick r. Curr Pharm Des. 2004;10(30):3781-96. doi: 10.2174/1381612043382684. Curr Pharm Des. 2004. PMID: 15579071 Review.

5

Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex.

Frédérick R, Pochet L, Charlier C, Masereel B. Frédérick R, et al. Curr Med Chem. 2005;12(4):397-417. doi: 10.2174/0929867053363108. Curr Med Chem. 2005. PMID: 15720249 Review.

6

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.

Frédérick R, Ooms F, Castagnoli N Jr, Petzer JP, Feng JF, Schwarzschild MA, Van der Schyf CJ, Wouters J. Frédérick R, et al. Acta Crystallogr C. 2005 Sep;61(Pt 9):o531-2. doi: 10.1107/S0108270105023140. Epub 2005 Aug 10. Acta Crystallogr C. 2005. PMID: 16143772

7

3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa.

Frédérick R, Robert S, Charlier C, de Ruyck J, Wouters J, Pirotte B, Masereel B, Pochet L. Frédérick R, et al. J Med Chem. 2005 Dec 1;48(24):7592-603. doi: 10.1021/jm050448g. J Med Chem. 2005. PMID: 16302799

8

Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.

Frédérick R, Charlier C, Robert S, Wouters J, Masereel B, Pochet L. Frédérick R, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2017-21. doi: 10.1016/j.bmcl.2005.12.070. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413781

9

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.

Frédérick R, Dumont W, Ooms F, Aschenbach L, Van der Schyf CJ, Castagnoli N, Wouters J, Krief A. Frédérick R, et al. J Med Chem. 2006 Jun 15;49(12):3743-7. doi: 10.1021/jm051091j. J Med Chem. 2006. PMID: 16759116

10

Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative.

Frédérick R, Robert S, Charlier C, Wouters J, Masereel B, Pochet L. Frédérick R, et al. J Med Chem. 2007 Jul 26;50(15):3645-50. doi: 10.1021/jm061368v. Epub 2007 Jun 20. J Med Chem. 2007. PMID: 17580844

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