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Page 1
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: lamponi s. J Med Chem. 2012 Aug 9;55(15):6948-67. doi: 10.1021/jm300802s. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22783984
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Butini S, Gemma S, Brindisi M, Borrelli G, Lossani A, Ponte AM, Torti A, Maga G, Marinelli L, La Pietra V, Fiorini I, Lamponi S, Campiani G, Zisterer DM, Nathwani SM, Sartini S, La Motta C, Da Settimo F, Novellino E, Focher F. Butini S, et al. Among authors: lamponi s. J Med Chem. 2011 Mar 10;54(5):1401-20. doi: 10.1021/jm101438u. Epub 2011 Feb 14. J Med Chem. 2011. PMID: 21319802
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: lamponi s. J Med Chem. 2012 Dec 13;55(23):10387-404. doi: 10.1021/jm300831b. Epub 2012 Nov 21. J Med Chem. 2012. PMID: 23145816
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor.
Mugnaini C, Pedani V, Casu A, Lobina C, Casti A, Maccioni P, Porcu A, Giunta D, Lamponi S, Solinas M, Dragoni S, Valoti M, Colombo G, Castelli MP, Gessa GL, Corelli F. Mugnaini C, et al. Among authors: lamponi s. J Med Chem. 2013 May 9;56(9):3620-35. doi: 10.1021/jm400144w. Epub 2013 Apr 18. J Med Chem. 2013. PMID: 23544432
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.
Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V. Brizzi A, et al. Among authors: lamponi s. Bioorg Med Chem. 2014 Sep 1;22(17):4770-83. doi: 10.1016/j.bmc.2014.07.006. Epub 2014 Jul 12. Bioorg Med Chem. 2014. PMID: 25065940
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility.
Mugnaini C, Brizzi A, Ligresti A, Allarà M, Lamponi S, Vacondio F, Silva C, Mor M, Di Marzo V, Corelli F. Mugnaini C, et al. Among authors: lamponi s. J Med Chem. 2016 Feb 11;59(3):1052-67. doi: 10.1021/acs.jmedchem.5b01559. Epub 2016 Jan 26. J Med Chem. 2016. PMID: 26756097
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. Brindisi M, et al. Among authors: lamponi s. J Med Chem. 2016 Mar 24;59(6):2612-32. doi: 10.1021/acs.jmedchem.5b01812. Epub 2016 Mar 7. J Med Chem. 2016. PMID: 26888301 Free article.
Development of novel cyclic peptides as pro-apoptotic agents.
Brindisi M, Maramai S, Brogi S, Fanigliulo E, Butini S, Guarino E, Casagni A, Lamponi S, Bonechi C, Nathwani SM, Finetti F, Ragonese F, Arcidiacono P, Campiglia P, Valenti S, Novellino E, Spaccapelo R, Morbidelli L, Zisterer DM, Williams CD, Donati A, Baldari C, Campiani G, Ulivieri C, Gemma S. Brindisi M, et al. Among authors: lamponi s. Eur J Med Chem. 2016 Jul 19;117:301-20. doi: 10.1016/j.ejmech.2016.04.001. Epub 2016 Apr 5. Eur J Med Chem. 2016. PMID: 27150036
104 results