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Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: saponara s. J Med Chem. 2012 Aug 9;55(15):6948-67. doi: 10.1021/jm300802s. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22783984
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.
Brindisi M, Butini S, Franceschini S, Brogi S, Trotta F, Ros S, Cagnotto A, Salmona M, Casagni A, Andreassi M, Saponara S, Gorelli B, Weikop P, Mikkelsen JD, Scheel-Kruger J, Sandager-Nielsen K, Novellino E, Campiani G, Gemma S. Brindisi M, et al. Among authors: saponara s. J Med Chem. 2014 Nov 26;57(22):9578-97. doi: 10.1021/jm501119j. Epub 2014 Nov 7. J Med Chem. 2014. PMID: 25343529
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. Brindisi M, et al. Among authors: saponara s. J Med Chem. 2016 Mar 24;59(6):2612-32. doi: 10.1021/acs.jmedchem.5b01812. Epub 2016 Mar 7. J Med Chem. 2016. PMID: 26888301 Free article.
110 results